June 5, 2020

The Niche

Knoepfler lab stem cell blog

Rais et al

4 min read

Researchers probing how to reprogram cells into powerful stem cells (induced pluripotent stem cells or IPSCs) and what the molecular mechanisms are behind this process have become entangled in a conflict. Of course over the years scientists including stem cell scientists have had their share of disagreements and debates in the past including heated ones, but this reprogramming clash has taken it up a notch beyond past ones and has some unique elements to it. For example, this scientific clash is unfolding largely in the public domain …Read More

2 min read

A team at the Weizmann Institute of Science in Israel led by Jacob Hanna reports today near perfect reprogramming efficiency to make induced pluripotent stem cells (iPSCs) by eliminating a single factor called Mbd3 from the cellular equation. On first glance, the Nature article (Rais, et al.) seems to be all about boosting cellular reprogramming efficiency to close to 100%. If that were the whole story of this paper then it would likely not draw major interest and probably would not have been published in Nature. Why? The …Read More