reciprocal CRISPR

Weekly reads: ‘junk DNA’, COVID chaos, CRISPR CasΦ, & postdoc opps, more

Retroviral-genes-Junk-DNA-NIHsmall

Here are our weekly recommended regenerative medicine and other notable science reads including a few things on COVID. It’s been quite an interesting week. “Junk DNA” is not so junky, role in differentiation NIH scientists showed how ancient retroviral genes, or “junk DNA”, may play a role in helping stem cells decide to become neurons. This …

Weekly reads: ‘junk DNA’, COVID chaos, CRISPR CasΦ, & postdoc opps, more Read More »

Reciprocal CRISPR gene editing in pediatric glioma: defining mechanisms & testing drugs

reciprocal-CRISPR-mutant-H3.3

My lab’s new paper in Communications Biology focused on high-grade pediatric glioma that have mutant histone variant H3.3 and we did something fairly novel that we are calling reciprocal CRISPR. Kids with these tumors have a near zero survival rate within a few years of diagnosis so we as a field desperately need something new to give …

Reciprocal CRISPR gene editing in pediatric glioma: defining mechanisms & testing drugs Read More »