July 14, 2020

The Niche

Knoepfler lab stem cell blog

Robert Morey

6 min read

In a new, thought-provoking paper today in Nature, Shoukhrat Mitalipov and a multi-institutional team report a significant advance toward potential novel ways to treat mitochondrial diseases. What are these illnesses? Mitochondrial diseases are rare, but devastating disorders caused by genetic mutations. Today they are largely impossible to treat in meaningful ways other than palliative care. Some of the mutations causing these diseases are in nuclear DNA, while others are in the mitochondrial DNA (mtDNA). The main current approach to prevention is preimplantation genetic diagnosis (PGD) …Read More

4 min read

Just how good are human embryonic stem (ES) cells made by therapeutic cloning via nuclear transfer? How do they compare to induced pluripotent stem (iPS) cells or traditional ES cells made from IVF embryos? A new paper in Nature directly tackles these key questions, but first a bit of context. Three separate groups have now successfully made ES cells using somatic cell nuclear transfer (SCNT), with the successful technique first reported by the lab of Shoukhrat Mitalipov at OHSU last year. I have reviewed those three therapeutic cloning papers …Read More