June 6, 2020

The Niche

Knoepfler lab stem cell blog

Shinya Yamanaka

4 min read

Has it really been 10 years since induced pluripotent stem cells (aka IPS cells or IPSC) came onto the scene in the stem cell field? Yes, it was a decade ago that now Nobel Laureate Shinya Yamanaka (山中伸弥) published that seminal Cell paper on reprogramming to make mouse IPS cells and then human IPS cells came the next year. From the moment I read that first mouse IPS cell paper, I was very excited about the science and the ideas in it. The domain …Read More

3 min read

The second day of ISSCR 2016 started off with a great session on pluripotency and plasticity, and the first talk was by Shinya Yamanaka. He changed the title of his talk to “Reprogramming of Cells and Scientist”. As with my other posts on this meeting, this one is a stream of quotes and impressions from the talk. The beginning was more autobiographical on his part and then the second half was on basic science. I really enjoyed this talk overall. It’s now been a …Read More

3 min read

Shinya Yamanaka is one of my favorite fellow scientists. His research is creative and rigorous along with having huge clinical implications. At the same time, Dr. Yamanaka sees the big picture and he’s very open about talking about real life as a scientist. I really appreciate both levels. In the past I interviewed him for my blog on the clinical use of IPS cells. In a new interview with Yamanaka by The Japan Times, he says quite a lot of important things. The field should …Read More

2 min read

There’s a growing stream of stem cell good news of late. Stem cell biotech, TiGenix, reported encouraging Phase 3 allogeneic results on stem cells. A big milestone. I can’t wait to see the actual data. Its product, Cx601, has so far been safe and effective for perianal fistulas in Crohn’s disease. See more from Alexey on this. CIRM has funded the largest public stem cell bank in the world. Want to make a withdrawal? Asterias reported some great news. It’s AST OPC-1 product showed some signs of encouraging efficacy in the …Read More

25 min read

By Michael Cea Jeanne Loring of the Scripps Research Institute in La Jolla, California kindly sat down with me at the ISSCR annual meeting for a broad discussion of her history, views on the field and developments in the science. I found Jeanne a refreshing character, as I did a number of others I was fortunate to meet in Sweden. Her style I can only best describe as natural. It must be the Southern California air or something but there is a definite quality of relaxed …Read More

3 min read

As many of you know, the pioneering, first of its kind IPS cell clinical study in Japan has been suspended as I first blogged about here.2020 Update: I believe a version of this study is ongoing. In the comments section of that blog post there has been a helpful overall discussion that has involved Dr. Masayo Takahashi, the leader of the IPS cell trial. It is great that Dr. Takahashi has been participating in this discussion and I commend her for that openness. This …Read More