June 1, 2020

The Niche

Knoepfler lab stem cell blog

SOX2

3 min read

There’s a new paper in Cell Stem Cell on esophageal organoids that has really caught people’s attention. It is entitled, “3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling.” It comes from a team led by Jianwen Que. Update: I didn’t realize when I first did this post that there were 2 related esophageal organoids papers in the same issue of the journal and the second one led by James M. Wells at Cincinnati Children’s has some cool …Read More

4 min read

CRISPR and IPS cells are two of my favorite things so when they come together as in a cool, new paper from Sheng Ding’s lab, I’m excited to read it and curious as to what the scoop is. Since 2006-2007 when mouse and human reprogramming were first reported, many different methods have been explored to make induced pluripotent stem (IPS) cells. Along the way we’ve all learned quite a lot about how pluripotency is regulated, whether it is in the context of maintenance or …Read More

5 min read

Is there a stem cell connection between the brain and aging? Could a type of brain stem cell control whole body aging? A recent big Nature article from the lab of Dongcheng Cai argues an emphatic “Yes” to these questions, at least in mice. In the Zhang, et al paper, entitled “Hypothalamic stem cells control ageing speed partly through exosomal miRNAs”, their team reports the claim that a narrow population of hypothalamic stem cells are directly fighting aging of the entire murine body via a …Read More

1 min read

Enjoy! A brunch for the brain. News and links CBER Director Focuses on Flexibility to Advance Regenerative Medicines Lab-Grown Blood Stem Cells Produced at Last Transplanted stem cells become eggs in sterile mice Maryland fund awards $8.5 million for stem cell research Positively good news from Asterias for CIRM-funded stem cell clinical trial for spinal cord injury Sergio Canavero: Will His Head Transplants Roll? Century-old tumours offer rare cancer clues Papers Identification of hair shaft progenitors that create a niche for hair pigmentation (see Figure 2D above) Tip110 Deletion Impaired Embryonic and …Read More

4 min read

A new Cell paper from Juan Carlos Izpisua Berlmonte’s group has made headlines about anti-aging across the globe because it suggests that the four core induced pluripotent stem cell (IPSC) factors use by Shinya Yamanaka to make IPSC can reverse aging. I’ve pasted the graphical abstract from the paper below and done a quick journal club style overview based on a quick skim of the paper. Some of the media headlines are rather dramatic on this story. For instance, in a story on it over at STAT …Read More