January 18, 2021

The Niche

Trusted stem cell blog & resources

stap cell poll

3 min read

The STAP cell mess that began in January of this year has in some ways quieted down. In a broader sense, I believe that STAP is now and will be in the future viewed as a scandal that revealed some less than ideal aspects to the world of biomedical science and publishing. Where does this all stand today? A New STAP-Like Paper? The most recent development is the publication of a new paper pointed out by a number of people to me as perhaps STAP-like. …Read More

2 min read

Now that it appears that the authors have all consented to eventually have both of their STAP cell Nature papers retracted, what’s next for STAP? Who knows, but below is my attempt at a top 10 list of STAP predictions looking ahead. I hope I’m wrong about several of them. 10. No insight will come from Nature on the STAP review or editorial process and there will be no indication from them that anything went wrong at their level.  I predict the journal will …Read More

2 min read

Japanese news media are reporting that Haruko Obokata and other key authors have agreed to retract the Nature STAP cell letter, but not the Nature article. This is a major development and a peculiar one because to many in the  field it is the Nature STAP cell article that is the more flawed of the two Nature papers on STAP. Why would Obokata and her colleagues agree to retract the STAP letter from Nature, especially after for so long categorically rejecting the idea? I suspect they are under pressure from other …Read More

2 min read

For more than 3 months I’ve been doing a tracking poll on the sentiments of the readers of this blog about STAP stem cells. The question is “Do you believe in STAP Stem Cells?” The result are summarized in the graph above. The latest poll results from period #9 are somewhat of a surprise. The overall trend for Poll #9 on STAP stem cells would seem to indicate a significant shift toward a more positive view, at least for the category “Close Yes”, meaning …Read More

2 min read

Sometimes a situation is so bad or stressful that it just calls out for some comic relief and the STAP cell mess seems to be one of those. Below are various silly attempts at STAP humor to hopefully release some of that stress. (By the way you might enjoy this 2020 piece on whatever happened to Obokata). Some doodling of hypothetical Dr. Bob and Dr. Sue trying to replicate STAP in a lab and being super stressed with a surprising consequence… Other names for STAP …Read More

2 min read

A RIKEN committee has rejected an appeal by Dr. Haruko Obokata regarding its finding of research misconduct related to two papers in Nature claiming the production of so-called STAP cells and STAP stem cells. Earlier the committee had ruled that Obokata had allegedly engaged in misconduct and that there problems with the research. Obokata appealed this ruling on April 8 and now the committee has rejected her appeal. The results of their deliberations were summarized succinctly thusly: The committee, taking into account the points …Read More

3 min read

A paper has been published reporting that repeated attempts to make so-called “acid bath stem cells” have failed. At the end of January it was claimed in two Nature papers that a mild acid treatment created pluripotent or even totipotent stem cells that that the authors termed “STAP cells” or “STAP stem cells” (collectively referred to here as “STAP cells” in this post). I reviewed the papers here on the blog when they came out and raised key questions about them. Since that time …Read More

2 min read

Whether STAP cells are real or baloney, much went wrong with the actual STAP cell Nature papers and the research reported in them by Obokata and her co-authors. Who is responsible for these two deeply flawed papers? I’m not sure we have enough information at this time to know definitively how responsibility/blame should be apportioned, but first author Dr. Haruko Obokata has so far received the lion’s share of the blame. Is that just? Her institution RIKEN seems to be placing almost all of the …Read More

1 min read

What’s up with STAP cells? Do people belief in them or not? Our STAP poll #8 polling results on STAP are in with more than 1000 respondents. The poll question was “Do you believe in STAP cells?” I will start STAP poll #9 soon. The poll #8 results remain about the same but there has been a slight shift toward more people indicating they are at least leaning positive. Again, recall that this polling is not scientific.

5 min read

The ultimate fate of the two Nature STAP cell papers remains in troubled limbo. One of the senior STAP cell authors, Dr. Sasai, held a news conference yesterday in Japan that included a call for the papers to be retracted. He was variously quoted as believing in STAP cells or alternatively as just thinking it was an unproven hypothesis. Whether STAP cells or STAP stem cells are real or not, overall the STAP cell situation has been disastrous. Can biomedical science learn anything from this …Read More