January 18, 2021

The Niche

Trusted stem cell blog & resources

stem cells aging

5 min read

A fitness guru named Ben Greenfield has now reported self-injecting non-FDA approved stem cells from US Stem Cell. He says the stem cells came from a clinic that lost a big federal court case 9 days ago. Greenfield posted a Facebook video of the actual injection, which he narrates. There’s some text along with the video. Together they raises many troubling questions. Date of video vs. date of court ruling Greenfield says in the text describing the video that the stem cells were sent …Read More

2 min read

Every so often here on The Niche I list science and news articles worth a look as “weekend reads”. Below is my list for this weekend. Enjoy! The first article doesn’t really fit into the other main categories, but the title “herding brains” caught my eye. Stem Cells Stem cells and regenerative capacity in aging brain, article in Cell. Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain. Does this kind of research have relevance to humans? See interesting, complex graphical abstract …Read More

4 min read

Historically, the main route of proposed healing via stem cell therapy was cell replacement. In this way of thinking the transplanted cells engrafted (took up home) in the patient’s tissue and replaced dead or diseased cells. However, interest continues to grow in other possible modes of healing by stem cells that don’t rely on cell replacement. In today’s post I cover 4 other possible mechanisms for stem cell therapy to aid health. Secreted factors An alternative, not mutually exclusive model to cell replacement is …Read More

2 min read

What is the Billionaire’s blood & stem cell club and how does one get into that? The focus of what I’m satirically calling this “billionaire’s club” is on anti-aging and prolonging life. If you have a lot of money and are willing to take risks on yourself toward some specific goal such as staying young or fixing some disease or injury via spending big bucks, the young blood & stem cell club might be right for you. Billionaires tend to be risk-takers any way, …Read More

4 min read

If you want to fight aging, should you turn to stem cells? Does the idea of stem cells to battle getting old even make any sense? The answer is, “it depends.” It’s a really interesting area conceptually and technically for stem cells. A theory. There is evidence that things that happen to our endogenous stem cells are linked to aging. In my book Stem Cells: An Insider’s Guide, which I’m hoping to get a new edition out for next year, I even proposed the …Read More

4 min read

I’ve been blogging about stem cells now for about 8 years and the recent level of hype about and fluffy media coverage of Celularity, the biotech spun out of Celgene, ranks right up here with the most extreme past cases I’ve seen. What is Celularity and who is its leadership? It’s a new biotech focused on placental stem cells with some familiar, well-known leaders including Bob Hariri and Peter Diamandis, and famous tech names on their board including John Scully and Bill Maris, along …Read More

5 min read

Stem cells for flu? For me, that idea is new. Some months back there was buzz about the stem cell biotech Longeveron related to its report on early trial data on testing infusions of mesenchymal stem cells for frailty in the aged. Frailty that pops up in some aging folks can manifest in a variety of ways and contribute both to reduced quality of life and mortality. This week a PR firm for Longeveron sent out an email suggesting that the company’s investigational stem …Read More

5 min read

Imagine an old man and a teenager sitting side by side, with blood flowing from the kid to the oldster in a stab at anti-aging. Sort of like a one-way fountain of youth via blood flow…Sci-fi? People are kind of trying it in the real world. A self-described ‘clinical trial’ of a sort by a company called Ambrosia essentially lets you buy an infusion of a younger person’s blood in an attempt at anti-aging for $8,000. Interested? Reportedly tech guru Peter Thiel is: “I’m not convinced yet …Read More

5 min read

Is there a stem cell connection between the brain and aging? Could a type of brain stem cell or the exosomes it secretes control whole body aging? A recent big Nature article from the lab of Dongcheng Cai argues an emphatic “Yes” to these questions, at least in mice. In the Zhang, et al paper, entitled “Hypothalamic stem cells control ageing speed partly through exosomal miRNAs”, their team reports the claim that a narrow population of hypothalamic stem cells are directly fighting aging of the …Read More