October 19, 2020

The Niche

Knoepfler lab stem cell blog

stem cells for arthritis

1 min read

Papers and news for weekend reads. Hostile Takeover: Glioma Stem Cells Recruit TAMs to Support Tumor Progression by Yu Shi, Yi-fang Ping, Xia Zhang, Xiu-wu Bian in Cell Stem Cell YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate self-renewal and Vascular Mimicry of Stem-like Cells by Namrata Bora-Singhal, Jonathan Nguyen, Courtney Schaal, Deepak Perumal, Sandeep Singh, Domenico Coppola, Srikumar Chellappan in Stem Cells Jacob Hannah’s team posts on bioRxiv in support of their original Mbd3/NuRD findings. RetractionWatch: Judge rules most of PubPeer’s commenters can remain anonymous. The key …Read More

2 min read

Can stem cells treat the different forms of arthritis that plague 100s of millions of people across the globe? A couple years back I did a post in my disease focus series on the potential of stem cells to be used as treatments for osteoarthritis (OA). OA affects almost 30 million people in the U.S. alone. It leads to loss of cartilage in joints such as the knee, where a person can end up with bone on bone (see image at right). Almost 1% …Read More

2 min read

About one in ten people around the world will develop osteoarthritis (OA) at some point in their lives. In the U.S., it is the major cause of disability. This is an extremely serious illness in terms of its impact on society. At this time there is little in the way of effective treatments for OA. Most treatments are designed to reduce pain and enhance function, not address the actual underlying condition. One exception is join replacement surgery such as knee replacement. OA is a …Read More