October 26, 2020

The Niche

Knoepfler lab stem cell blog

Stem Cells Parkinson’s Disease

2 min read

Japan is a leader in stem cell and regenerative medicine research, and in particular in clinical translation toward the bedside. Induced pluripotent stem cell (IPSC)-based investigational therapies are rightly an area of focus in Japan given their invention by Nobel Laureate Shinya Yamanaka. Small clinical studies based on IPSC have been initiated there for several diseases including related to vision loss and Parkinson’s Disease. David Cyranoski over at Nature reports on a new, different stem cell clinical effort in Japan for vision loss with …Read More

5 min read

Each year I make a list of stem cell predictions for the following year and I’ll release my predictions for 2019 soon, but first I’m grading how my 20 predictions for 2018 turned out. It seems I did better than usual predicting what would happen this year. I only got a couple partial credit or were hard to grade. The rest were right. Here are my 20 predictions verbatim that I made in late 2017 for what would happen in 2018. 1. Combo cell-gene …Read More

2 min read

A much-anticipated induced pluripotent stem (IPS) cell trial for Parkinson’s Disease reportedly will soon launch led by Professor Jun Takahashi. The news broke on Yahoo Japan, which included an unusual number of appropriately sober statements regarding the trial, even though it is an exciting trial as well, compared to most media stories on stem cells. Parkinson’s Disease is a result of a loss of dopaminergic neurons in the brain so it is a particularly attractive target disease for stem cells, which can be readily …Read More

5 min read

Every year in December I go out onto a limb and make stem cell predictions for the coming year as I did in late 2017 for this year. Then usually around the 1/2-way point through the year I check in on how the predictions are faring so far at that point. In this post I give my 2018 predictions (pasted below) the 1/2-way point checkup. Things are off to a reasonably strong start for the old stem cell crystal ball.  For the grading, green is …Read More