January 18, 2021

The Niche

Trusted stem cell blog & resources

Stem Cells

3 min read

Today’s post is the latest edition of my weekly recommended reads, which this week include Fate Therapeutics, COVID-19 updates, AAMC, and more including some great pubs such as one on 2 modes of PRC2 function. Also check out this handy resource: Helpful 2020 List of Stem Cell Journals and this blast from the past post of 10 years ago: Keep Your Stem Cells Away From BPA. I’ll start with the mid-August 2020 recommended pubs and then go to the media items, but first I wanted to …Read More

3 min read

There is always plenty of complicated, mixed-bag news on the stem cell and regenerative medicine front so it’s great to highlight when there’s some good news out there. Today’s post includes several such upbeat items. At the bottom I’ve included a list of some recent interesting publications as well. Good news on vision front: jCyte Therapy Deal with Santen Pharmaceutical. David Jensen over at California Stem Cell Report reported on this blockbuster deal for a quarter of a billion dollars. Jensen wrote: “The California …Read More

3 min read

It’s notable how the FDA now considers gene-editing a kind of regenerative medicine. This means that various gene therapy products in development technically qualify as regenerative therapies. Ever since the agency began its rapidly growing regenerative medicine advanced therapy (RMAT) designation program, we’ve seen an increasing number of gene therapy biotechs and products qualify as RMATs. As a result, the RMAT-qualified gene therapies get to go into a speedier lane of FDA oversight. Today’s post is a mix of recommended reads in the regenerative …Read More

6 min read

Last year around this time I took my annual plunge to make 20 predictions for the coming year for the stem cell and regenerative medicine field. I even made a crystal ball graphic to highlight the complexity of the stem cell ecosystem into which these predictions were embedded (see image) for 2019. How’d I do? Below I grade my 20 predictions for this year. You can in addition see my grading of my 2018 predictions here. In the next week or so I’ll also …Read More

2 min read

Once or twice a month I do a post on notable stem cell publications and news, which often but not always include research on iPS cells. It’s sort of a recommended reads kind of post, but I often include one or two things that aren’t necessarily recommended exactly yet seem kind of surprising or novel in some ways. Here’s today’s list. One bit of news first On the RMAT front: “FDA Grants RMAT Designation for CAR T-Cell Therapy for Multiple Myeloma.”  You can see …Read More

2 min read

365 days a year, 24 hours a day stem cells are growing in labs around the world, providing a never-ending stream of data and products, with real hope, good news, and lots of surprises. You can see some past examples of good news in the stem cell and regenerative medicine field highlighted on The Niche here. Today’s post brings 2 examples of recent good news and a brain organoid surprise. And one bonus more about space and when you’d run out of air (or not …Read More

2 min read

Who doesn’t like a good science contest with prizes? There are so many beautiful pictures of cells including some that are stem cell-related out there in journals and on the web. We can find such images are in papers. Sometimes people post such great cell pics on the web too. In the past I’ve run various contests here on The Niche. Perhaps my favorite was a stem cell image contest that attracted some amazing entries (see composite included here). In that spirit, I’m again …Read More

3 min read

Last year an odd pub  made the big claim that the interstitium is a new organ. I didn’t buy that. Now an over-the-top stem cell advertisement that recently ran in the San Diego Union-Tribune (U-T) is piggybacking off of the supposed “interstitium as new tissue” claim to make all kinds of other claims about some mystery “stem cell” pill. You can see a picture at left of the ad that a The Niche reader sent to me. The word “cure” there is like a …Read More

2 min read

Here are some articles that look especially interesting on stem cells, cancer, and CRISPR. I was just at the SNO meeting in SFO on childhood brain tumors so those are on my mind more. Childhood cerebellar tumours mirror conserved fetal transcriptional programs (Nature) Childhood brain tumors “think” they are building organds in fetuses. H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo. (Acta Neuropathologica) from Suzy Baker-led team. H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and …Read More

2 min read

Over the last couple of years the marketing of unproven clinic injections of non-FDA-approved stem cells seems in open-throttle mode. What used to just be on the web here and there is now on billboards, newspapers, flyers, infomercials, and on TV. It’s possible that millions of dollars are being spent yearly on advertising this stuff, which means far more than that huge amount is being taken in as revenue by clinics and their associated businesses such as marketing firms. But there’s a different and …Read More