July 9, 2020

The Niche

Knoepfler lab stem cell blog

Stimulus-trigged fate conversion of somatic cells into pluripotency

2 min read

When I asked the readers of this blog what they felt was the biggest stem cell story of 2014 in a poll, they overwhelmingly picked the STAP cell scandal. For background on STAP you can toggle through the many STAP cell pieces on this blog here, see a STAP timeline, and a STAP image gallery. Basically, STAP was a bogus scientific claim about a supposedly simple reprogramming method to make powerful stem cells induced by cellular stress. Despite many flaws in this STAP research and the …Read More

3 min read

The STAP cell mess that began in January of this year has in some ways quieted down. In a broader sense, I believe that STAP is now and will be in the future viewed as a scandal that revealed some less than ideal aspects to the world of biomedical science and publishing. Where does this all stand today? A New STAP-Like Paper? The most recent development is the publication of a new paper pointed out by a number of people to me as perhaps STAP-like. …Read More

2 min read

The reviews of a STAP paper submitted to and rejected by the journal Science in 2012 were posted at Retraction Watch yesterday. They filled in some gaps in the puzzle of the series of events that led to such flawed science being published in Nature in January 2014, but the reviews also raised more questions. Today, more STAP paper reviews have surfaced. ScienceInsider posted a piece with additional STAP paper reviews with these coming from Nature reviewers commenting on what would later become accepted and published by Nature only months later …Read More