May 31, 2020

The Niche

Knoepfler lab stem cell blog

therapeutic cloning

4 min read

Has it really been 10 years since induced pluripotent stem cells (aka IPS cells or IPSC) came onto the scene in the stem cell field? Yes, it was a decade ago that now Nobel Laureate Shinya Yamanaka (山中伸弥) published that seminal Cell paper on reprogramming to make mouse IPS cells and then human IPS cells came the next year. From the moment I read that first mouse IPS cell paper, I was very excited about the science and the ideas in it. The domain …Read More

1 min read

A lot has happened in 2014 in the stem cell and regenerative medicine field and so much of it has been good news. These positive developments are often the result of many years of creative, hard work by amazing teams of researchers. Here is my top 10 list of these exciting advances. 1. First IPSC study in humans by team led by Masayo Takahashi. 2. and 3. Major Diabetes advances: ViaCyte starts stem cell-based clinical trial for Diabetes and multiple teams of researchers make human …Read More

3 min read

Cloning of animals is becoming a big, global business. It turns out that this reproductive cloning of animals goes well beyond making duplicates of pets for sentimental customers at $100,000 a copy. Cloning of livestock by agribusinesses is becoming fairly common. Some are also trying to de-extinct woolly mammoths by cloning too, something that I oppose (see top 5 reasons why it might be a really bad idea) even though admittedly it sounds pretty cool. More broadly, factory-scale production of copied animals is an expanding business. …Read More

2 min read

A new human therapeutic cloning paper is out today, the third in a matter of months. This one is from the lab group of Dr. Dieter Egli published in Nature demonstrating production of nuclear transfer embryonic stem cells (NT-ESCs) from an adult human somatic donor via somatic cell nuclear transfer (SCNT). This human SCNT paper follows on the heels of a similar paper (Chung, et al.) from Bob Lanza’s group published in Cell Stem Cell and the pioneering Mitalipov human SCNT paper (Tachibani, et al.) …Read More

1 min read

I recently did a poll asking readers of my blog to vote on the iPS cell paper of the year for 2013. The vote kind of seesawed at the beginning, but in the end with 100 votes cast the paper by the Hannah lab on near-perfect iPS cell production won out (see votes at left). In second place was the Deng lab paper on all-chemical reprogramming. I suspect that just a couple years ago, this paper would have won by a landslide, which I …Read More