July 11, 2020

The Niche

Knoepfler lab stem cell blog

transdifferentiation

3 min read

Every year I do predictions for the stem cell field for the coming year. You can see my full post on my predictions for this year here. Stay tuned soon for my predictions for 2014. How’d I do for 2013 with my predications? Each prediction for this year that I made last year is bolded and my assessment now of how I did for each is in green or red. I did reasonably well for 2013. Sometimes predictions get mixed in with what hopes or …Read More

4 min read

What if you could reprogram cells inside of an organism to a different fate and, for instance, make IPS cells? We can, right? But when most of us think about making induced pluripotent stem (iPS) cells, we imagine it all happening in a little plastic dish in our labs or in our colleague’s labs, not in an actual organism. A cancer research team at the Spanish National Cancer Research Center took a very different approach reported in a hefty Nature article. They made iPS cells inside of …Read More

3 min read

Back-to-back papers (here and here) in Nature Biotechnology report the transdifferentiation (now often simply referred to as “direct reprogramming”) of plain old fibroblasts into brain cells called oligodendrocyte progenitor cells (OPCs). OPCs are a remarkably useful kind of brain cell that generates myelin, which insulates nerves. OPCs are thought to have great therapeutic potential for a number of pathological conditions including Multiple Sclerosis (MS) and spinal cord injury (SCI). The two teams included one from Case Western Reserve University School of Medicine led by Paul …Read More

2 min read

In previous years I’ve done yearly predictions for the coming year’s events in the stem cell world (see predictions for 2011 and 2012 predictions). I did pretty well in my predicting stem cell events for this year (see analysis here) scoring a respectable 70%. Isn’t that a C-?,you might ask. No, when it comes to stem cell predictions anything better than 50% is an A. Below are my prognostications for the stem cell field for 2013. I’m taking some more risks this year, but you only …Read More