October 19, 2020

The Niche

Knoepfler lab stem cell blog


2 min read

The still mysterious BioGatekeeper had challenged Yamanaka’s IPS cell patent claiming that it was obvious. The potential implications were huge given the commercial interest in translating IPS cell technology. For background see here, here, and here. There’s pretty much zero information on BioGatekeeper otherwise. Despite the potential seriousness of this patent challenge, just a few days ago the Patent Trial and Appeal Board (PTAB) denied the challenge so for all intents and purposes BioGatekeeper’s effort is dead. A big hat tip to reader Shinsakan. You …Read More

4 min read

Who is trying, via the name BioGatekeeper, Inc., to nullify Yamanaka’s patent on cellular reprogramming to produce induced pluripotent stem (iPS) cells? The readers of this blog never cease to amaze me. What an informed, energetic, bright group. Within just days they may have collectively shed some light on an intriguing mystery in the stem cell field surrounding the question that started this post. This past week the mysterious organization BioGatekeeper, Inc. filed a challenge to the Yamanaka Patent. The basis of the challenge is the assertion that cellular reprogramming was …Read More

3 min read

A new patent dispute has exploded in the stem cell field related to induced pluripotent stem (iPS) cells. What’s going on? In 2006, Shinya Yamanaka reported cellular reprogramming to create mouse induced pluripotent stem (iPS) cells in Cell and the next year multiple groups along with Yamanaka’s reported creating human iPS cells. It’s no exaggeration to say this was a blockbuster development for the cell and developmental biology fields and Yamanaka later went on to win the Nobel Prize for this discovery. Another element …Read More

2 min read

I recently held a flash 48 hour contest for free tickets to the World Alliance Forum on the future of stem cells at which Yamanaka and others will be speaking. Congrats to the winners, Sai Vemula and Johnathon Anderson. Here are their winning entries. Sai Vemula Editor, SSSCR-International, UC Berkeley, Molecular and Cell Biology B.A. This forum provides a unique opportunity to get a glimpse of the field from national and global perspectives and lets me go beyond the science and learn about various economical, …Read More