The Niche

Stem Cell & Regenerative Med Newsletter

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Stem cells & the philosopher's stone, P53, thyroid organoids

I hadn't remembered the history of the philosopher's stone until reading a new review article about stem cells and aging. Here's the article. Is the philosopher’s stone to rejuvenate blood stem cells an epigenetic regulator? Nature Aging. This preview kind of piece discusses how inhibiting a specific factor called PHF6 can "rejuvenate" HSCs in mice. I think a punnier title …
philosopher's stone

Clinical utility & examples of unipotent vs. multipotent stem cells

mesenchymal cells
What are examples of unipotent and multipotent stem cells? More broadly, stem cells have the ability to do two key things. They can make more of themselves through a process called self-renewal. Also, they have the ability to differentiate into other cell types. This latter property is called potency. Taken together this means by definition that a true stem cell …