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The Niche
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Stem Cell & Regenerative Med Newsletter
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Weekly reads: human CRISPR, MRT risks, private IRBs, skincare
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It's funny how sometimes there are many new articles about one general topic like this week with heritable (and somatic) human CRISPR gene editing and related tech. There are clear reasons for optimism in the somatic arena given advancing trials. Germline editing remains highly questionable in my view even just technically. Then there are loads of ethical issues. On a …
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Heart stem cells trial mostly disappoints but is oversold
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Are there endogenous adult heart stem cells that are useful in cardiac disease or can stem cell infusions help ailing hearts? As to the first question, the adult heart does not appear to have meaningful numbers of true stem cells. Further, testing the idea of infusions of stem cells for heart disease has so far been giving largely negative results over two-plus …
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Stem cell research ethics topics: organoid consciousness & embryo models
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Someday could human brain organoids get to the point of having organized human-like thoughts? Even consciousness? The more time passes, the less likely I think this is. It's not impossible, but brain organoids have big limitations in that regard. To be clear, I don't mean brain organoids having some vaguely human brain-like electrical activity. Even monolayers of cultured neurons can do that. …
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