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The Niche
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Stem Cell & Regenerative Med Newsletter
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Weekly reads: DNA methylation, H3 K27M in glioma, memory wipe, teeth
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I've been more interested in histones and their modifications versus DNA methylation when it comes to epigenetics and chromatin. In part this has just been because I have studied histones so much more. For example, we have been knocking out the two histone variant H3.3 genes, H3f3a and H3f3b, now for a decade. My lab also is studying H3.3 mutations in …
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Is DNA methylation destiny? Diving into new epigenetic clock research
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I've been thinking more about the steady stream of epigenetic clock research out there. How convincing is the research on such clocks? Do they tightly relate to human biological age? The related notion of turning back such hypothetical clocks to reverse aging is exciting but controversial. It doesn't help that some are hyping all of this and already selling stuff. …
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