Paul Knoepfler

Dr. Paul Knoepfler (@pknoepfler) is a biomedical scientist, science writer, advocate, and cancer survivor.Paul_TED

Mission. His philosophy is to make a transformative positive difference in biomedical science and wider communities both through innovative research and via novel, risky approaches to local and global educational outreach.

His research interests are primarily focused on the epigenomics of cancer and stem cells with a particular interest in pediatric tumors (see Knoepfler Lab page here).

Knoepfler is a Professor at UC Davis School of Medicine in the Department of Cell Biology and Human Anatomy (see Departmental Page here). At UC Davis he is also a faculty member of the Genome Center, the Comprehensive Cancer Center, the Institute for Regenerative Cures (aka UC Davis Stem Cell Center), and the Institute for Pediatric Regenerative Medicine. He received his BA in English Literature from Reed College and PhD from UCSD School of Medicine in Molecular Pathology. He did his postdoc with Bob Eisenman at The Hutch in Seattle, focused on MYC function in stem cells and cancer.

He is the author of Stem Cells: An Insider’s Guide and more recently GMO Sapiens on issues related to CRISPR use in humans, a book targeted to both a lay audience and scientists. For more on his concerns on heritable use of CRISPR in people, see his TED talk here.

He runs a popular stem cell research and policy blog. He has received a number of awards for science and advocacy (you can read more on Wikipedia).

3 Comments


  1. Just wondered what you thought about the outrageous proposed sale of Ocata
    I can’t believe those in control are going to let this leader of Regen med. be stolen by the crooked management team and the Japanese conglomerate.
    I hope you have reached out to anyone you might know to at least have them look in to this travesty.
    AMD,MMD,platelets,blood,lupus and chrons.Letting some other country benefit from all this American treasure can’t be allowed to stand.

    I know you will do the right thing.

    Disillusioned Edward


  2. Dr. Knoepfler,
    What are your thoughts on Dr. Purita’s clinic down in Florida? http://www.stemcellorthopedic.com/about-dr-purita.html
    Do you think he is in this just to make money? I have talked to several people that have been treated by him for knee arthritis and have experienced pain relief and improved function. Of course, he is not running any clinical trials comparing his treatments to placebo. And, what are your thoughts on Regenexx?
    As a patient, I have considered going to one of these clinics for treatment since other treatments have not worked and there are few options.
    Dr. Purita says that his stem cell plus PRP injections are not a “cure” but on his website it says, ” More detailed data from early patients is being collected. The following is in knee and hip patients with severe arthritis who were told they needed a joint replacement surgery:
    The great majority of knee patients reported more than 50% relief of symptoms and more than half of them had greater than 75% relief.
    The great majority of hip patients reported more than 50% relief and most of them reported more than 75% relief.”
    And, there are some articles that support the use of SVF injections to improve pain and function:
    http://www.ncbi.nlm.nih.gov/pubmed/26609244
    http://www.ncbi.nlm.nih.gov/pubmed/26257790
    http://www.ncbi.nlm.nih.gov/pubmed/26238455
    http://www.ncbi.nlm.nih.gov/pubmed/25706817
    http://www.ncbi.nlm.nih.gov/pubmed/24326779
    http://www.ncbi.nlm.nih.gov/pubmed/26336958
    http://www.ncbi.nlm.nih.gov/pubmed/26357483

    I want the FDA to protect us and obviously double blind randomized controlled studies are needed but I also don’t want the FDA to impede progress.
    It seems like Europe, Australia, and Asia are way ahead of us in terms of orthopedic regenerative treatment options.

    Thanks!


  3. Dr. Knoepfler
    You have a Dr. Centeno on your website giving comments about other stem cell clinics. He runs one himself (very expensive, by the way) in northern CA. What amount of credibility do you give him and his clinic? How are we, the nonexperts, able to judge who is honest and integritous and who is not?

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