The Knoepfler Lab conducts stem and cancer cell as well as chromatin/epigenetics research at the UC Davis School of Medicine.
Our team has two big picture goals: (1) catalyzing the development of more effective treatments for cancers based on targeting stem cell-related machinery in tumorigenesis and (2) producing safer stem cell-based regenerative medicine therapies. We are particularly interested in how chromatin and epigenomic machinery regulate normal stem cell fate and how perturbations of these pathways leads to human disease including cancers. We are in addition investigating the epigenomic mechanisms in cellular reprogramming and tumorigenesis in terms of cellular plasticity.
We focus on three main types of molecules that are part of these systems: the Myc family of proto-oncogenes, the novel pluripotency-related oncogenes DPPA4/DPPA2, and lately we are especially focused on the histone variant H3.3. All have roles in normal stem cells and in disease. We use a combined approach to determine the mechanisms by which these factors function including genetic, genomic, cell biological, and protein biochemistry methods. We have a strong track record of high impact publications in these areas.
You can contact Dr. Knoepfler at: [email protected].
The Knoepfler Lab currently receives funding from NIH and the Alex’s Lemonade Stand Foundation.
We are currently looking for a talented new researcher to join our team as a postdoctoral fellow:
An NIH and foundation-funded postdoctoral fellow position in the Knoepfler Lab at UC Davis School of Medicine is open. The focus of research will be on cancer and stem cell epigenomics. Studies will include functional genomics assays, ChIP-Seq, chromatin configuration, CRISPR genetics work, and cell biological research.
To apply: E-mail [email protected] a 1-page research overview of experience and career goals, a CV, and contact information for 3 references. For more information visit Knoepfler lab website http://www.chromatin.com.
Applicants must have a PhD, an MD, or both. Preference will be given to applicants who do not already have postdoctoral experience, but who have a strong track record as graduate students of biological research including publication of their work. Genomics, next generation sequencing, bioinformatics, cancer biology, and/or stem cell experience would be a plus. Excellent written and oral communication skills are required.
To apply: E-mail [email protected] a 1-page overview of research experience and career goals, a CV, and contact information for 3 references.