Weekly reads: brain aging, perinatal stem cell clinics, $1M lab meat fine bill

brain aging

What happens during brain aging and how can we tell if dementia is coming? Are there particular early hallmarks? There are an increasing number of medical tests for predicting or detecting dementia. Alzheimer’s disease can often be detected early. But what do patients or their doctors do with such information? Until recently there weren’t any …

Weekly reads: brain aging, perinatal stem cell clinics, $1M lab meat fine bill Read More »

Weekly reads: cool olfactory tuft cells, T-cell therapy, NK cells

Olfactory epithelium, Olfactory histology

There’s a fascinating type of olfactory cell. These so-called tuft cells have unusual characteristics, especially for nose cells. I had never heard of them before until reading a new article. The inside of the nose may not seem like a very attractive place but there are cool “nose stem cells” in there.  More broadly, there …

Weekly reads: cool olfactory tuft cells, T-cell therapy, NK cells Read More »

9th Circuit hearing on FDA appeal of Cell Surgical Network case: maybe encouraging?

Cell Surgical Nework

I was able to watch some of the 9th Circuit Court hearing today on the FDA appeal of its loss in the Cell Surgical Network lawsuit. This post is my brief impressions as a scientist. What went down? Do the three judges seem to be leaning one way or another? The ruling in this case …

9th Circuit hearing on FDA appeal of Cell Surgical Network case: maybe encouraging? Read More »

Man could get 240 yrs for amniotic fluid for knees Medicare scam

A Justice Department press release details how a physician’s assistant (PA) in Texas was convinced of fraud related to amniotic fluid injections. This story tells us some important things about how Medicare handles things versus the FDA approach to such things. Amniotic fluid scam A jury found Ray Anthony Shoulders, a PA at a pain …

Man could get 240 yrs for amniotic fluid for knees Medicare scam Read More »

Weekly reads: Xist & autoimmune disease in women, Crohn’s disease, dumb headline of the week

Xist ,auto immune disease

Readers of The Niche have asked me many questions about stem cells for autoimmune disease but the puzzle of why women get these conditions more often than men hasn’t come up before here. For instance, why is MS so much more common in women than men? It’s remained somewhat of a mystery over the years. …

Weekly reads: Xist & autoimmune disease in women, Crohn’s disease, dumb headline of the week Read More »

Long-term hope on stem cells for deafness

stem cells for deafness

A reader of The Niche recently asked me, “What about stem cells for deafness?” It’s a great question and, as they pointed out, stem cells for vision loss gets much more attention. I’ve covered the translational progress of stem cells to treat many diseases but there has been less progress for deafness in the regenerative …

Long-term hope on stem cells for deafness Read More »

Perspectives 10 years after STAP cells: the culture of science, misconduct, & hopes for progress

Haruko-Obokata-小保方-晴子-

Exactly ten years ago today, on January 29, 2014, I wrote about two new Nature papers on so-called STAP cells. The papers claimed that stress alone could convert regular non-stem cells into some of the most powerful stem cells. More specifically, the authors claimed to make pluripotent stem cells similar to iPS cells this way. …

Perspectives 10 years after STAP cells: the culture of science, misconduct, & hopes for progress Read More »

Weekly stem cell reads: cancer paper mess at DFCI, H3.3, knees, surfer keeps on posting

Sholto David, stem cell, cancer retractions

It’s another one of those ‘double-grant’ weekends of grant writing (on brain cancer) and reviewing, but I’m still trying to find a bit of time for some other reading. There was some important news this week including a big mess of problematic papers at Dana Farber Cancer Institute (DFCI). Recommended reads Here’s the new WaPo …

Weekly stem cell reads: cancer paper mess at DFCI, H3.3, knees, surfer keeps on posting Read More »

Textbook case of bad media on ‘stem cell treatment’ clinic: Kirk Cousins Caribbean trip

Kirk Cousins, stem cell treatment

It’s frustrating to see so much bad media coverage of celebrity trips to clinics to get supposed stem cell treatment of various kinds. Part of the concern here stems from ordinary people taking risks by following the example of the famous people.  Good journalism should ask tough questions, talk to experts, and not yield an …

Textbook case of bad media on ‘stem cell treatment’ clinic: Kirk Cousins Caribbean trip Read More »

Weekly reads: MiMedX & Kimera Labs FDA warnings, NYT on Bryan Johnson, MUSE cell trial

AXIOFILL, MiMedx

Placental biologics firm MiMedx and exosome company Kimera Labs both recently received FDA warning letters. The letter to MiMedx was related to its placental biologics products and procedures. The new warning to Kimera Labs was about its exosome products and an amniotic product. Let’s compare these letters starting with the one to MiMedX. MiMedx warning letter …

Weekly reads: MiMedX & Kimera Labs FDA warnings, NYT on Bryan Johnson, MUSE cell trial Read More »