In the past month or two there has been a steady stream of good news in the stem cell and regenerative medicine world. Here are three examples starting with Fate Therapeutics.
Fate Therapeutics
Fate Therapeutics announced the first US IND for an induced pluripotent stem cell (IPSC)-related product. Its cleared product, FT500, is an off-the-shelf natural killer-based cancer immunotherapy.
I expect more to come in the next couple years so good news now and likely more to come. IPSC-based trials are picking up in Japan too with trials related to vision loss and Parkinson’s Disease led by stem cell power couple Masayo Takahashi and Jun Takahashi, as well as a new heart study. Moving forward in the next 5-10 years how much will be allogeneic versus autologous? It’s interesting to follow this given how ~10 years when IPS cells were first reported the emphasis was entirely autologous.
ARM update
The Alliance for Regenerative medicine (ARM) gave a very up-beat state of the field recently. You can go through the presentation here. The “state of the field briefing” mentions 32% annual ARM growth over recent years and 906 regenerative medicine companies globally (see map from ARM).
Other highlights include a number of recent product approvals in different countries: Spark Therapeutics’ LUXTURNA, Avita’s RECELL, Gilead/Kite Pharma’s Yescarta, MiMedx‘s Amniofix & EpiFix, Novartis’ Kymriah, and TiGenix (Takeda)’s Alofisel. The ARM
update also mentions that there are more than 1,000 clinical trials in our area including 92 phase III trials, which is great.
UC Davis Stem Cells
Some cool, promising work right here at UC Davis on a novel stem cell approach for spina bifida got a boost with a big award of CIRM funding. I’ve seen my UCD Health System colleagues Diana Farmer and Aijun Wang present data on this early effort and even met one of the dogs who spontaneously have spina bifida, Arthur, who got a stem cell infusion.
The idea behind the investigational stem cell therapy for spina bifida is that the stem cells will grow to protect the spinal cord from injury. The intervention requires an in utero surgical step. It’s early days on this work, but it looks promising.
what ever came of Astellas research with Robert Lanza are they still progressing ?
Paul – seems some are not aware of the reported clinical safety & early efficacy results of the conducted trials to-date using differentiated cell therapy products derived from iPSC reprogramming technology.
Eye – http://www.cdb.riken.jp/en/news/2017/researches/0404_10328.html
GvHD – https://ash.confex.com/ash/2018/webprogram/Paper110432.html
One study was in Japan using a personalized patient specific “Autologous” approach and the other was conducted in the UK using an off-the-shelf universal “Allogeneic” product.
See also Jeanne Loring’s recent Guest Post on Auto & Allo approaches: https://ipscell.com/2019/01/autologous-or-allogeneic-a-stem-cell-question-guest-post-from-jeanne-loring/, in additon to a number of other threads here at The Niche on Pluripotent therapies in development.
To my knowledge the other iPSC clinical applications underway have yet to report.
There are a handful of iPSC based translational efforts in total to-date and another handful or two nearing the clinic in various prep stages.
Cheers
iPSCs and hESCs are the same…hESCs just got a 10-year headstart.
up today there no clinical evidence of ipsc are useful
Are you saying as of today, there is no clinical evidence that induced pluripotent stem cells are useful? Admin, is this true?
I really appreciate your coverage of promising stem cell research. Thank you, Paul.