Search Results for: gvhd

Mesoblast MSCs Quell Peds GvHD; On Road to FDA Approval?

MSCs-mesenchymal-stem-cells-stromal-cells-small

Graft-versus-host disease (GVHD) is counterintuitive In the weeks and months following a transplant, a major concern is the recipient’s immune system rejecting the “foreign” biological material. But in GVHD, the opposite happens: transplanted tissue unleashes a horde of T cells that spark a cascade of inflammation, within 100 days. Typically, GVHD follows a bone marrow …

Mesoblast MSCs Quell Peds GvHD; On Road to FDA Approval? Read More »

Patients stem cell Q&A#1: can clinic injections cause GVHD?

Colonic_graft-versus-host_disease-GVHD

People ask me questions about stem cells all the time so I decide to do a new blog series answering your questions. Today’s post is  the first in this new stem cell Q&A series. Past series have included my Elephant in the Lab series that provides some insights into the craziness that sometimes goes on …

Patients stem cell Q&A#1: can clinic injections cause GVHD? Read More »

Cynata approval for 1st ever allo trial of IPSC-derived MSCs for GVHD

Cynata

Cynata Therapeutics Limited has received approval from UK regulators to start a first-of-its-kind allogeneic IPSC-based trial of MSCs for graft versus host disease (GVHD). Cynata also had some big news a couple weeks back with a deal with Fujifilm. The company is aiming to recruit 16 patients to test whether the MSCs (a type of adult …

Cynata approval for 1st ever allo trial of IPSC-derived MSCs for GVHD Read More »

What is HSCT & its possible roles in MS treatment?

Selma-Blair-HSCT

Patients regularly reach out and ask me about something called HSCT. “What is HSCT?” and is it proven as a therapy? Often the patients asking about this have multiple sclerosis (MS) or some other autoimmune disease. I’m not a physician so I can’t give medical advice, but as a stem cell biologist here at UC …

What is HSCT & its possible roles in MS treatment? Read More »

Stem cell therapy side effects & risks: infections, tumors & more

stem-cells-eyes side effects

What are the possible stem cell therapy side effects of going to an unproven clinic? This is a common question I get asked. Most often it is asked by patients who reach out. Check out the YouTube video below on our stem cell channel. If you like such videos please subscribe to our channel. Side …

Stem cell therapy side effects & risks: infections, tumors & more Read More »

Stem cell therapy: the good, the bad, & the muddy waters

stem-sells-marketing

How can you tell who to trust in the world of stem cell therapy? What information can a patient trust? Once upon a time about a dozen years ago it seemed a much simpler question. There were universities and biotech companies doing legit research as well as clinical trials, and there were physicians doing bone …

Stem cell therapy: the good, the bad, & the muddy waters Read More »

Mesoblast stock hit on gloomy data on stem cells for COVID-19

mesoblast ceo dr silvio itescu

I’ve been closely following the arena of stem cells for COVID-19 since the pandemic broke including the efforts of Mesoblast. Mesoblast unlikely to meet primary endpoints in Phase III COVID trial Now, the firm got bad news as its DSMB reported that they are unlikely to meet the primary endpoint for their Phase III trial …

Mesoblast stock hit on gloomy data on stem cells for COVID-19 Read More »

Overview of IPS cell prospects for clinical impact

IPS-cell-clincial-trials-map

IPS cell research is a growing area of promise for regenerative medicine. These stem cells, also known as iPSCs or more formally as Induced Pluripotent Stem Cells, are engineered cells that are programmed to function the same way as embryonic stem cells. They can be differentiated into possibly any type of cell that is needed for …

Overview of IPS cell prospects for clinical impact Read More »

Recommended reads: Bee brain, COVID, from Russia with stem cells, pubs

Reprogramming-roadmap-reveals-route-to-human-induced-trophoblast-stem-cells

Reading to them was one of my favorite things to do with my kids when they were little, but it’s a long way from Goodnight Moon to this week’s list of recommended reads, although “bee brain” may have got their attention. Please take a minute to complete our The Niche reader survey for a chance …

Recommended reads: Bee brain, COVID, from Russia with stem cells, pubs Read More »