Search Results for: h3.3

Weekly reads: H3.3 on the brain, Texas bill, HSCs

H3f3a, histone H3.3, knockout

It’s always exciting when your lab has a new paper and my team just published a study knocking out the H3f3a gene in mice, which codes for histone H3.3 protein. We found that loss of this gene leads to lethality at a late stage of embryonic development. There were also indications of more specific phenotypes …

Weekly reads: H3.3 on the brain, Texas bill, HSCs Read More »

Weekly stem cell reads: COVID kidney, FDA letter, H3.3, EO Wilson

EO Wilson

Happy New Year and get ready for another 364 more days of stem cell excitement and craziness in 2022. In the next day or two I’ll post my predictions for this new year. Recommended reads EO Wilson obit by Carl Zimmer in NYT. Who’s the next EO Wilson or someone like him with such big impact these …

Weekly stem cell reads: COVID kidney, FDA letter, H3.3, EO Wilson Read More »

Allis lab Science paper on histone H3.3 in pediatric brain cancer

Allis-H3.3-paper-165x3001

It has been fascinating in the last year to see the unfolding story of mutations in histone variant H3.3 in pediatric glioblastoma and related tumors. It seems amazing that in just over a year, a whole new area of cancer research has rapidly progressed. As I discussed in a recent post, histone H3.3 is a …

Allis lab Science paper on histone H3.3 in pediatric brain cancer Read More »

Histone H3.3: giving cells epigenetic flexibility

chromosomal bridge in histone H3.3 knockout

A relatively newly recognized, important player in the stem cell field is a molecule called histone H3.3. Histones are key components of chromatin with integral roles in regulating almost all aspects of cell behavior through orchestrating functions such as transcription and chromosome segregation. Histone H3.3 knockout My lab has just (April 9) published new studies …

Histone H3.3: giving cells epigenetic flexibility Read More »

Brain cancer: why histones including H3.3 are so important

Why are most brain cancers so difficult to treat leaving the unfortunate patients who suffer from them in dire circumstances so often? The short answer is that we don’t know why. This lack of understanding is like a wall standing between the cures and us for these patients. We have to climb or knockdown this …

Brain cancer: why histones including H3.3 are so important Read More »

Weekend reads: WaPo blows it on COVID, paper-mill detector, adult pluripotent stem cells

"Hofstenia miamia, three-banded panther worms. Credit: Mansi Srivastava and Kathleen Mazza-Curll"

Imagine writing or editing an article for the WaPo about risky, unproven medical interventions for COVID that desperate patients might consider. Then you link directly to the websites selling this stuff in your article. What the heck? WaPo links to risky long COVID “treatments” By linking, you not only are driving customers to these firms, …

Weekend reads: WaPo blows it on COVID, paper-mill detector, adult pluripotent stem cells Read More »

Paper sparks renewed interest in transdifferentiation & clinical potential

transdifferentiation, iOPCS

There was a time when I thought transdifferentiation based approaches might quickly move into clinical trials. Then things kind of cooled off. We didn’t see many papers reporting methods to transdifferentiate cells. I still think that this technology, sometimes called direct reprogramming, has major potential. A new paper on making human brain cells this way got …

Paper sparks renewed interest in transdifferentiation & clinical potential Read More »

Histone code series: H3K27me3 & H3K27ac functions & roles in diseases like DIPG

ASCL1 in K27M tumors, H3K27me3 loss

Histone proteins such as histone H3 are often popping up in science writing and news sometimes includes specific modified forms of H3 including one that we scientists call H3K27me3. What is in this article What is H3K27me3? | The histone code | H3K27ac and H3K27me3 function | H3K27 and human disease | References The goal of today’s post …

Histone code series: H3K27me3 & H3K27ac functions & roles in diseases like DIPG Read More »

Weekly reads: our new brain tumor paper, levitation, dear doctor, Japan, more

brain tumor, H3.3 K27M, ASCL1

There’s nothing quite like getting a new paper out as a scientist running a research lab so this week we can celebrate our new pediatric brain tumor study. I’ll start the weekly reads with that paper. Of course, getting new grants is amazing too but there’s more of a feel of completion after a paper …

Weekly reads: our new brain tumor paper, levitation, dear doctor, Japan, more Read More »

Recommend reads: CRISPR baby guy free, DNMT3, sperm, Editas, hearing loss, reprogramming

Dura et al sperm development

We often don’t think of them that way but reproductive cells like sperm and egg are also relatives of stem cells, and it turns out that there are stem cells that make the reproductive cells too like sperm stem cells. Sperm and germ cell stem cells DNMT3A-dependent DNA methylation is required for spermatogonial stem cells …

Recommend reads: CRISPR baby guy free, DNMT3, sperm, Editas, hearing loss, reprogramming Read More »