Search Results for: h3.3

Allis lab Science paper on histone H3.3 in pediatric brain cancer

Allis-H3.3-paper-165x3001

It has been fascinating in the last year to see the unfolding story of mutations in histone variant H3.3 in pediatric glioblastoma and related tumors. It seems amazing that in just over a year, a whole new area of cancer research has rapidly progressed. As I discussed in a recent post, histone H3.3 is a …

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Histone H3.3: giving cells epigenetic flexibility

chromosomal bridge in histone H3.3 knockout

A relatively newly recognized, important player in the stem cell field is a molecule called histone H3.3. Histones are key components of chromatin with integral roles in regulating almost all aspects of cell behavior through orchestrating functions such as transcription and chromosome segregation. Histone H3.3 knockout My lab has just (April 9) published new studies …

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Brain cancer: why histones including H3.3 are so important

Why are most brain cancers so difficult to treat leaving the unfortunate patients who suffer from them in dire circumstances so often? The short answer is that we don’t know why. This lack of understanding is like a wall standing between the cures and us for these patients. We have to climb or knockdown this …

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Weekly stem cell reads: COVID, tail regeneration, aging

tail regeneration

The stem cell field lost a great scientist and friend this week with the passing of Meri Firpo from metastatic breast cancer. I’m going to post a tribute to Meri from several of us sometime this coming week. I’m in a bit of a somber mood but still trying to write, read, and do all …

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Weekly reads: New FDA guidance, brains, MSCs, senescence

human mouse marmoset brain

This week marked the release of new draft FDA guidance on cell and gene therapies. Is the FDA kind of like the guidance counselor at school or more like the principal? It probably depends on many factors. I also find it funny how pretty much everyone in academia and biotech industry works to be compliant …

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Weekly reads: CRISPR’d marsupial, outpatient recovery post stem cell transplants, Parkinson’s, pubs

CRISPR'd baby opossums.

This edition of The Niche weekly reads has a bit more good news than usual including on stem cell transplants. It’s nice to see positive developments like some recipients of hematopoietic stem cell transplants being able to stay at home afterwards. Also, a reminder. You have until July 31 to enter our stem cell video …

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Weekly reads: cancer stem cells & other pubs plus a puzzler

kyu yum nature cancer stem cells niche

Cancer stem cells are one of the most interesting areas of research, intersecting the stem cell and cancer fields. Today’s weekly reads post highlights some new cancer stem cell articles along with some other interesting papers. I also note a recent weak stem cell clinical trial paper that is not a recommended read but is …

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Weekly reads: oncodevelopmental factors, iPSC cancer vaccine, more

stem cell vaccine paper ouyang et al

One of my main research interests is in oncodevelopmental factors. These include factors that are important both for normal stem cell biology and development as well as driving cancer when misregulated. One example includes the MYC family of proto-oncogenes. When I was a postdoc I got especially interested in trying to understand the normal role …

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Weekly reads: stem cells for spina bifida & diabetes trials, pubs

arthur the dog helps test stem cells for spina bifida

It’s always great when there’s good news in the stem cell field and a new trial of stem cells for spina bifida here at UC Davis School of Medicine is very encouraging. So I’ll lead off with this story. Stem cells for spina bifida This pioneering work is led by Drs. Diana Farmer and Aijun …

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Recommended reads: stem cells on the brain, heart, COVID

ascl1 brain stem cells harris et al cell stem cell 2021 fig. 6

There are weeks when it seems like papers on stem cells keep popping up. It can be a challenge to keep up with reading all the papers you want to read. Other times it is cell biology news that keeps breaking. The big news of the past week or so was unfortunately the concerning development …

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