Search Results for: in vivo reprogramming. 

Perspectives on David Sinclair anti-aging Cell pub & in vivo reprogramming

methuselah mouse, anti-aging

About twenty years ago a science story made big news of a so-called anti-aging Methuselah gene. Methuselah gene and anti-aging The claim was that this DNA conferred long life on people. Hence the name Methuselah, which refers to a man from the Bible who reportedly lived 969 years. The so-called Methuselah gene was at first not a […]

Perspectives on David Sinclair anti-aging Cell pub & in vivo reprogramming Read More »

Weekly reads: reprogramming aging, astrocytes, cartilage, ChatGPT

Let’s start with a couple of new pieces on in vivo reprogramming. The idea here is to do something like making iPS cells but doing it inside organisms and not quite pushing cells all the way back to pluripotency. Just younger, healthier cells. Why do that? The goal is to achieve a kind of anti-aging

Weekly reads: reprogramming aging, astrocytes, cartilage, ChatGPT Read More »

Defining epigenetic reprogramming, cellular reprogramming & rejuvenation

epigenetic reprogramming

Epigenetic reprogramming is a term used in cell biology that is increasingly ending up in news stories too. Unfortunately, some folks, especially in the cellular rejuvenation and anti-aging space, are getting this term and other things confused. Just to start off, epigenetic reprogramming does not specifically mean cellular rejuvenation. The goal of today’s post is

Defining epigenetic reprogramming, cellular reprogramming & rejuvenation Read More »

Stem cell journal club: dishing on Nature paper on making iPS cells inside mice

What if you could reprogram cells inside of an organism to a different fate and, for instance, make IPS cells? We can, right? But when most of us think about making induced pluripotent stem (iPS) cells, we imagine it all happening in a little plastic dish in our labs or in our colleague’s labs, not

Stem cell journal club: dishing on Nature paper on making iPS cells inside mice Read More »

Transdifferentiation meets gene therapy to tackle heart disease

The leading cause of death in America and many other countries of the world is cardiovascular disease (CVD) including heart attacks and strokes. In fact, CVD kills and disables more people than most often top killers combined including cancer. The myth that CVD is a “man’s disease” only makes the situation worse as in reality CVD

Transdifferentiation meets gene therapy to tackle heart disease Read More »