Search Results for: mesenchymal

Mesenchymal cells or MSCs: definition, clinical potential, challenges

mesenchymal cells, MSCs, mesenchymal stem cells, multipotent stem cells

I confess that I’m old enough to remember when the acronym MSC stood unambiguously for “mesenchymal stem cells”, but should it refer to a broader term like “mesenchymal cells”? The field has moved in that direction. I think that’s the best way to go too and I’ll explain why. The goal of today’s post is …

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Stem Cell Word Cloud: Mesenchymal Dominates in 2015

word-cloud-stem-cell15

What does a stem cell word cloud tell us about the field? Word clouds are fun and informative ways to do textual data mining. I’ve done some in the past that have providing penetrating looks at science including at the whole field of science in 2014. What has the stem cell field overall been focusing on …

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Where Kimera Labs fits into sphere of exosome companies

Kimera labs exosome

Today’s post takes a close look at the exosome manufacturer Kimera Labs in the context of the main exosome companies. What are exosomes? Exosomes are microscopic bubbles or vesicles produced by cells. Exosomes contain many cellular substances that are biologically active. Some of these materials may be helpful clinically, while others could pose risks. Clinical outcomes …

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Heart stem cells trial mostly disappoints but is oversold

heart stem cells

Are there endogenous adult heart stem cells that are useful in cardiac disease or can stem cell infusions help ailing hearts? As to the first question, the adult heart does not appear to have meaningful numbers of true stem cells. Further, testing the idea of infusions of stem cells for heart disease has so far been giving …

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Weekly reads: bat stem cells & viruses, Lineage Cell, He Jiankui visa

bat stem cells, stem cells

Occasionally when I write a post there is an angry reaction to it in the blog comments, which was the case for my recent fact-check of the LifeWave X39 patches.  As you can see in that post, I didn’t find convincing data to either back up the claimed stem cell connection. In my opinion, there …

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Does NurOwn from BrainStorm Cell Therapeutics still provide hope for ALS?

Chaim Lebovits, CEO of BrainStorm Cell Therapeutics.

What is the cell therapy for ALS called NurOwn? How strong is its potential as a treatment for ALS? I’ve been following the biotech BrainStorm Cell Therapeutics for many years. Patients keep asking me about NurOwn ALS prospects. They’re looking for hope. Today’s post is a close look at NurOwn and at BrainStorm as a …

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Fact-checking stem cell stroke therapy: hope but not there yet

Stem cell stroke therapy

Stem cell stroke therapy research has generated buzz over the years. The goal of today’s post is to fact-check claims about supposed stem cell stroke therapies and educate readers on where clinical research stands. There is some real hope here in the long run, but things have been greatly exaggerated at times. Some clinics are …

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Clinical utility & examples of unipotent vs. multipotent stem cells

mesenchymal cells

What are examples of unipotent and multipotent stem cells? More broadly, stem cells have the ability to do two key things. They can make more of themselves through a process called self-renewal. Also, they have the ability to differentiate into other cell types. This latter property is called potency. Taken together this means by definition …

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Weekly reads: NurOwn, key gene screen, MS, Croce mess

Nurown BrainStorm

I get a lot of questions about stem cells for ALS and more recently people have been specifically interested in NurOwn from BrainStorm Cell Therapeutics. Recently, the FDA denied BrainStorm’s request for a BLA for NurOwn. The company felt its Phase III trial was encouraging. It sounds like they will move forward with a follow-up …

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Digging into the multiple ways to get stem cells

multiple ways to get stem cells

I get great questions from readers of The Niche including, “Are there multiple ways to get stem cells?” The answer is “yes.” Why is this important? The different sources of stem cells can impact both their use in basic research and their potential clinically. My goal in today’s post is to give an overview of …

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