Author name: Professor Paul Knoepfler, Ph.D.

Paul Knoepfler, Ph.D. is a Professor at UC Davis School of Medicine in Cell Biology and Human Anatomy. His lab does research on stem cells and cancer, especially from an epigenomic angle. He also has been working on policy and ethics matters for many years. The author of 3 books, he also has a popular TED talk on designer babies.

In support of the Roman Reed Spinal Cord Injury Research Act

Roman-Reed_2

Roman Reed has been a long-time, highly effective stem cell research advocate. He was one of the first recipients of The Niche Stem Cell Person of the Year Award.  For years here in California something called Roman’s Law provided crucial funding for research. Eventually the funding ran out so now it’s time to help make […]

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Weekly reads: NIH fetal tissue research ban, hESCs likely next, retraction spike, FDA CGT flexibility

Jay Bhattacharya

NIH just announced a fetal tissue research ban. We can also expect an end (or close to it) to funding of human embryonic stem cell (hESC) research soon. There have been signs these were coming. Fetal tissue research ban, hESCs likely next Here’s the announcement: NIH Announces Major Policy Shift to End Use of Human

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Stem cells for stroke hype awardee 10 years ago now tells a cautionary tale

Stem-cell-hype

About a decade ago, I started giving out stem cell hype awards, including one for a stem cells for stroke headline. It was way over the top: ‘Stanford researchers ‘stunned’ by stem cell experiment that helped stroke patient walk’. This is one of the most sensationalized stem cell headlines ever, but it’s not alone. What

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Weekly reads: FDA politics, Lineage Cell update, tuft cells & cancer, neuron mitochondrial transfer, dead celeb genomics

FDA

FDA politics and ideology-driven decision-making seem more complex than ever. Much of this is due to RFK Jr. being atop HHS. Before we dig into that, if you missed it, you might check out my predictions for the regenerative medicine field for the new year of 2026. It’s going to be a whirlwind of policy

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Weekly reads: organoids ‘pregnant’ with human embryos, Neuralink, biotech scorecard, iffy autism tests

pregnant organoid

What if humans can have kids without directly getting pregnant at all? Surrogacy may come to mind, but what if children can be produced without humans at all? A reproductive clinic would just use our cells. Getting even further into what feels like the sci-fi realm, what if you don’t even need regular sperm and

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2026 predictions: historic FDA shift, plausible mechanisms, bespoke tx, RFK Jr., biotechs, state AGs, peptides, embryos

stem cell predictions

I do yearly predictions for the stem cell and regenerative medicine field. Today’s post discusses my 2026 predictions. You can also see my 2025 stem cell predictions and their grades. It was one of the most accurate years. Now, there’s still a lot swirling around in the regenerative medicine field, the FDA, RFK Jr., politics,

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Weekly reads: the stem cell niche, tongue stem cells, autoimmune diseases

stem cell niche, tongue stem cells

The stem cell niche is one of my favorite areas of research that I don’t actually work on directly. At least my lab hasn’t studied it much so far. My sense is that many scientists have favorite areas of research that they don’t actually study themselves. Do you have an area of research that particularly

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Grading my 25 stem cell & regenerative medicine predictions for 2025

regenerative medicine, stem cell predictions

Toward the end of each year I make predictions for the stem cell and regenerative medicine field for the coming year. I’ve been doing this in some form for more than a dozen years. In today’s post I grade my 2025 predictions for the regenerative arena. Overall, the crystal ball didn’t disappoint even if the

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Colossal Biosciences wins 2025 The Screamers Award for science hype on dire wolf de-extinction claim

The Screamers Award, Science Hype Award

To my knowledge, The Niche’s The Screamers award is the only science hype award out there. There were many candidates this year, but one stood above the rest for extraordinary hype in science. Colossal Biosciences wins 2025 The Screamers science hype award Colossal Biosciences gets the nod because of their remarkable hype about supposedly de-extincting

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