August 8, 2020

The Niche

Knoepfler lab stem cell blog

autoimmune disease

3 min read

“HSCT Chicago Clinic Closing!” is the startling header in all caps on a patient-run Facebook page about a stem cell therapy clinical trial program at Northwestern University. What’s going on? Unfortunately, the promising field of hematopoietic stem cell transplantation (HSCT) for multiple sclerosis (MS) and other autoimmune diseases seems to have suffered an unexpected setback here. Dr. Richard Burt of Northwestern, one of the leading figures in the area of developing HSCT approaches for MS and other autoimmune disorders, is going on a sabbatical …Read More

3 min read

The idea of using stem cells for scleroderma seems a bit more promising today. A new NIH-funded study reported in the New England Journal of Medicine (NEJM) gives some hope for the use of a combination of a specific type of myeloablation and a transplant of hematopoietic stem cells (HSC). This approach yields improved long-term outcomes for patients with a severe form of scleroderma called systemic sclerosis. While survival rates for systemic sclerosis have improved it remains a very challenging condition with a significant …Read More