Informational Archives - Page 3 of 5

‘We don’t want to freak people out’: about that Jacob Hanna human embryo model startup

August 18, 2022 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Stem cell biologist Jacob Hanna has a new startup called Renewal Bio. Its goal is to harvest cells or tissues from human embryo or fetus models for clinical use. I believe that their commercial ambitions have so far outstripped careful thought and discussion in the broader community of researchers. There are major risks here for […]

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Histone code series: H3K27me3 & H3K27ac functions & roles in diseases like DIPG

August 9, 2022 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Histone proteins such as histone H3 are often popping up in science writing and news sometimes includes specific modified forms of H3 including one that we scientists call H3K27me3. What is in this article What is H3K27me3? | The histone code | H3K27ac and H3K27me3 function | H3K27 and human disease | References The goal of today’s post

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How brain organoids are transforming research

August 2, 2022 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Organoids including brain organoids are an exciting, relatively new area of research. This technology is having a powerful impact on biomedical science, which is the focus of today’s post. What’s in this post Definition of organoids | Brain organoids | Challenges for mini-brains | Cutting edge cerebral organoids | References Definition of organoids and brain organoids

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Weekly reads: freeze-dried cloning, FDA signals, stem cell escapees

July 10, 2022 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Cloning is one of those topics that both fascinates and kind of scares people, especially the idea of duplicating people. I regularly cover the topic here on The Niche because stem cell technologies are involved. Also, one form of the process sometimes called “therapeutic cloning” involves embryonic stem cells. Duplicating mammals has now long been

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What is an FDA warning letter & how should firms respond

June 21, 2022 / Professor Paul Knoepfler, Ph.D. / 10 Comments

Firms that are active in the biologics space face many possible challenges but the possibility of getting an FDA warning letter is one of the most intense. The goal of today’s post is to explain what an FDA warning letter is all about. This analysis includes what such a letter means and what steps come

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What are blastoids, roles in biomedical research, & ethical considerations

June 16, 2022 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Blastoids are lab-grown models of human embryos that represent a relatively new area of developmental biology research. The goal of today’s post is to give you everything you need to know about this topic. What’s in this article What are blastoids? | How are blastoids made? | Use in research | Blastoids challenges & Ethics

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Fact-checking VSEL stem cells & VSEL treatment

June 7, 2022 / Professor Paul Knoepfler, Ph.D. / 6 Comments

A few people in the stem cell field keep arguing that adult pluripotent stem cells exist, including so-called “very small embryonic-like stem cells” or VSEL stem cells. These days the supposed cells are called VSELs or V-cells too. Only a handful of researchers have ever been able to report finding and studying these cells. Others

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Review of stem cell hair transplant for baldness

November 2, 2021 / Professor Paul Knoepfler, Ph.D. / 8 Comments

Occasionally a reader of The Niche will ask me about stem cell therapy for hair loss and getting a stem cell hair transplant. I’m interested in this research because I’m fascinated by stem cells. Admittedly I don’t have as much hair as I used to so that’s sometimes on my mind too. So where do

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Stem cell therapy side effects & risks: infections, tumors & more

September 29, 2021 / Professor Paul Knoepfler, Ph.D. / 8 Comments

What are possible stem cell therapy side effects? This is a common question I get asked. Most often it is asked by patients who reach out. They usually refer to risks at unproven stem cell clinics Check out the YouTube video below on our stem cell channel including my video on stem cell therapy side

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Autologous vs allogeneic: all you need to know on therapy

March 22, 2021 / Professor Paul Knoepfler, Ph.D. / 4 Comments

There are many ways to classify different stem cells. These differences include yours versus someone else’s cells. Another distinct in a clinical sense is what we call an autologous vs allogeneic stem cell transplant. This post is focused on the difference between allogeneic (someone else’s cells) and autologous (your own) stem cell injections. As a

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