histone H3.3

Allis lab Science paper on histone H3.3 in pediatric brain cancer

Allis-H3.3-paper-165x3001

It has been fascinating in the last year to see the unfolding story of mutations in histone variant H3.3 in pediatric glioblastoma and related tumors. It seems amazing that in just over a year, a whole new area of cancer research has rapidly progressed. As I discussed in a recent post, histone H3.3 is a …

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Histone H3.3: giving cells epigenetic flexibility

chromosomal bridge in histone H3.3 knockout

A relatively newly recognized, important player in the stem cell field is a molecule called histone H3.3. Histones are key components of chromatin with integral roles in regulating almost all aspects of cell behavior through orchestrating functions such as transcription and chromosome segregation. Histone H3.3 knockout My lab has just (April 9) published new studies …

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Brain cancer: why histones including H3.3 are so important

Why are most brain cancers so difficult to treat leaving the unfortunate patients who suffer from them in dire circumstances so often? The short answer is that we don’t know why. This lack of understanding is like a wall standing between the cures and us for these patients. We have to climb or knockdown this …

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