There’s nothing quite like getting a new paper out as a scientist running a research lab so this week we can celebrate our new pediatric brain tumor study. I’ll start the weekly reads with that paper. Of course, getting new grants is amazing too but there’s more of a feel of completion after a paper …
Weekly reads: our new brain tumor paper, levitation, dear doctor, Japan, more Read More »
It has been fascinating in the last year to see the unfolding story of mutations in histone variant H3.3 in pediatric glioblastoma and related tumors. It seems amazing that in just over a year, a whole new area of cancer research has rapidly progressed. As I discussed in a recent post, histone H3.3 is a …
Allis lab Science paper on histone H3.3 in pediatric brain cancer Read More »
A relatively newly recognized, important player in the stem cell field is a molecule called histone H3.3. Histones are key components of chromatin with integral roles in regulating almost all aspects of cell behavior through orchestrating functions such as transcription and chromosome segregation. Histone H3.3 knockout My lab has just (April 9) published new studies …
Histone H3.3: giving cells epigenetic flexibility Read More »
Why are most brain cancers so difficult to treat leaving the unfortunate patients who suffer from them in dire circumstances so often? The short answer is that we don’t know why. This lack of understanding is like a wall standing between the cures and us for these patients. We have to climb or knockdown this …
Brain cancer: why histones including H3.3 are so important Read More »