Histones

Histone code series: H3K27me3 & H3K27ac functions & roles in diseases like DIPG

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ASCL1 in K27M tumors, H3K27me3 loss

Histone proteins such as histone H3 are often popping up in science writing and news sometimes includes specific modified forms of H3 including one that we scientists call H3K27me3. What is in this article What is H3K27me3? | The histone code | H3K27ac and H3K27me3 function | H3K27 and human disease | References The goal of today’s post […]

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Weekly reads: oncodevelopmental factors, iPSC cancer vaccine, more

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stem cell vaccine paper ouyang et al

One of my main research interests is in oncodevelopmental factors. These include factors that are important both for normal stem cell biology and development as well as driving cancer when misregulated. One example includes the MYC family of proto-oncogenes. When I was a postdoc I got especially interested in trying to understand the normal role

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Cool paper by Shawn Cowley Lab on the role of HDACs in ES cells

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Cowley-HDAC-knockout-278x3001

It was great being a postdoc in Bob Eisenman’s Lab at the Hutch in Seattle with colleagues like fellow postdoc Shawn Cowley. I loved it.  Bob is a great mentor (see more on my experience there here) and the scientific interactions in the lab were wonderful. It’s been fun and interesting to follow the work

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Cool Cell Stem Cell Paper From Ishii Team on Histones & Reprogramming

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Two of my favorite things are stem cells and histones. When they both come together in one paper and it’s in my favorite journal, Cell Stem Cell, you’ve got my full attention. My own lab is especially interested in the roles of histones and Myc in stem cells. So when I saw a paper a paper from

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