October 29, 2020

The Niche

Knoepfler lab stem cell blog

human genetic modification

3 min read

Something called, “The International Commission on the Clinical Use of Human Germline Genome Editing” has issued a new report on heritable human genome editing (HHGE). The Commission was convened by the U.S. National Academy of Medicine, the U.S. National Academy of Sciences, and the U.K.’s Royal Society. This post is my initial take on the summary of the lengthy report. I hope to have time to read the full report in coming weeks and it’s possible some new perspectives may emerge. Here is my thinking as …Read More

6 min read

By Guillaume Levrier Human germline editing has been done before. It will be done again in the future, as it is relatively easy to perform. No mechanism with the de facto ability to prevent it from being organized has yet been designed, let alone implemented. But the fact that germline editing has, can, and will happen again does not deprive anyone of their right to have an opinion on this capacity. The CRISPR Consensus symposium (see video below) set up at the Innovative Genomics Institutes …Read More

4 min read

Three national academy leaders have a new opinion piece in Science on what the community needs to do next regarding human germline editing now that we are most likely in the CRISPR babies era. Some of us have been wondering what the Academies and their empowered experts really think about this issue and what they are saying outside the public domain. Do some of them disagree with each other? There have been mixed messages. The new piece, entitled, Wake-up call from Hong Kong, gets a …Read More

4 min read

Did Chinese researcher He Jiankui really CRISPR gene edit the CCR5 gene in two embryos producing twin baby girls? In my opinion the answer is “no”, but probably not for the reason you might think at first. He proclaims gene edits He claimed he had made twin baby girls with “gene edits”, which I feel is unethical overall and risky to those babies. He’s announcement also may have been intentionally timed to occur right before an international meeting on human gene (or genome) editing last week …Read More