IPS cells Archives - Page 2 of 6

Perspectives on high-profile stem cell retraction in the making from Kyoto University

January 23, 2018 / Professor Paul Knoepfler, Ph.D. / 4 Comments

A researcher working at Kyoto University has reportedly engaged in misconduct leading to an institutional request for retraction of a paper from the journal Stem Cell Reports. The paper in question appears to have rather large-scale problems: “Kohei Yamamizu, a specially appointed assistant professor at the university’s Center for iPS Cell Research and Application, falsified all […]

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CRISPR to make IPS cells: review of new Ding lab paper

January 21, 2018 / Professor Paul Knoepfler, Ph.D. / 4 Comments

CRISPR and IPS cells are two of my favorite things so when they come together as in a cool, new paper from Sheng Ding’s lab, I’m excited to read it and curious as to what the scoop is. Since 2006-2007 when mouse and human reprogramming were first reported, many different methods have been explored to

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Adverse event in IPS cell (ips細胞) trial for vision loss in Japan: initial perspectives

January 16, 2018 / Professor Paul Knoepfler, Ph.D. / 3 Comments

A team of researchers at RIKEN and Kobe City Medical Center reported at a press conference today a serious adverse event in a clinical trial participant receiving an induced pluripotent stem cell (IPS cell)-based therapy for vision loss. According to Japan Times and Yahoo! Japan (in Japanese), the patient in question in the IPS cell

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Stem cell transplants: hIPSC and hESC behave similarly in brain & often fuse with host cells

August 24, 2017 / Professor Paul Knoepfler, Ph.D. / 8 Comments

What happens following pluripotent stem cell transplants into the brain? Are human IPS and ES cells going to function similarly in this context? We recently published a new translational paper on the behavior of human pluripotent stem cells when transplanted into the adult mouse brain in collaboration with my great UC Davis colleague, Dr. Veronica Martinez-Cerdeno.

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Takahashi team IPS cell vision paper marks major stem cell milestone

March 16, 2017 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Ring the bell for a stem cell milestone, specifically for iPS cell work. There’s been a whole lot of commotion about the NEJM article yesterday documenting the experiences of three women with macular degeneration who were blinded by non-FDA approved stem cell eye injections of fat stem cells at a business in Florida, but in the

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Yamanaka’s baby turns 10: ten IPS cell hot button bullet points

July 27, 2016 / Professor Paul Knoepfler, Ph.D.

Nobel Laureate Shinya Yamanaka, the first to produce induced pluripotent stem cells

Has it really been 10 years since induced pluripotent stem cells (aka IPS cells or IPSC) came onto the scene in the stem cell field? Yes, it was a decade ago that now Nobel Laureate Shinya Yamanaka (山中伸弥) published that seminal Cell paper on reprogramming to make mouse IPS cells and then human IPS cells

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Parkinson’s IPS cell trial in Japan switching to allogeneic

November 15, 2015 / Professor Paul Knoepfler, Ph.D. / 21 Comments

What’s better for stem cell trials such as for vision loss or Parkinson’s Disease: allogeneic or autologous cells? In a major shift earlier this year, the induced pluripotent stem (IPS) cell trial in Japan for treatment of macular degeneration (MD) switched gears from using the patients’ own cells (called “autologous”) to using banked cells from

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IPS Cell Immunogenicity, Clinical Insights, & Possible Solutions

August 23, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Can cells produced from autologous induced pluripotent stem cell (IPSC or IPS cell) cultures sometimes be immunogenic in patients? This key question has remained somewhat unsettled due to varied findings over the years (e.g. see here), but many of us had generally felt in the last couple years that IPS cell derivative immunogenicity in an

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Historic turning point for IPS cell field in Japan?

August 2, 2015 / Professor Paul Knoepfler, Ph.D. / 24 Comments

As many of you know, the pioneering, first of its kind IPS cell clinical study in Japan has been suspended as I first blogged about here.2020 Update: I believe a version of this study is ongoing. In the comments section of that blog post there has been a helpful overall discussion that has involved Dr.

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Landmark IPSC clinical study on hold due to genomic issue

July 1, 2015 / Professor Paul Knoepfler, Ph.D. / 42 Comments

The pioneering induced pluripotent stem cell (IPSC) clinical study in Japan led by top stem cell clinical researcher Dr. Masayo Takahashi has been stopped reports the WSJ in Japan. This development is confirmed by other sources and in a PDF report by RIKEN (in Japanese here). One patient was transplanted in September 2014 with their own IPSC-derived

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