Lung

COVID Traps Alveoli Cells in a Curious Progenitor State, Squelching Lung Regeneration

normal lung alveoli indicating examples at1 and at2 cells

Mere weeks into the COVID pandemic, stunning graphics began to appear depicting the path of devastation of SARS-CoV-2 through a human lung. It’s only recently that we’ve come to understand what, exactly, is happening on a cellular level. The new view is thanks to single-cell RNA-sequencing, which analyzes the abundance of messenger RNAs in individual …

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Fact check: Lung Health Institute & cell therapies for lung disease

the lung health institute

What should we make of clinics like the Lung Health Institute? These clinics sell unproven stem cell or regenerative therapies for lung disease. Overall, I’m extremely skeptical. I don’t believe it’s worth the cost. There are also going to be potentially serious health risks. Lung disease is a broad category including COPD, emphysema, pulmonary fibrosis, …

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Weekly reads: organoids, COVID-19, CIRM & cool new pubs

Human-intestinal-organoids-infected-with-SARS-CoV-2-white.-Credit-Joep-BeumerClevers-groupHubrecht-Institute

Organoids are providing a novel avenue into the pathogenesis of COVID-19 and novel models for drug screening. A number of new preprints on respiratory organoids shed new light in this area. They were highlighted in a Nature newsy piece, Mini organs reveal how the coronavirus ravages the body. It’s a challenge to study COVID-19 infections because just infecting …

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‘I’d need a drink’: WaPo deep dive on clinic firm Lung Health Institute

H-CYTE-Ann-Sells-Miller

Washington Post reporters William Wan and Laurie McGinley have a new piece on the unproven regenerative clinic firm the Lung Health Institute. This article has a number of surprises and new insights. Previously the Lung Health Institute was called just the Lung Institute. It was recently acquired by the publicly-traded company H-CYTE, stock symbol HCYT. In the …

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On stem cells for lungs the-profit clinic offerings don’t make much sense

lung stem cells, lung health institute

What’s the deal with lung stem cells and stem cells for lungs? For a long time researchers found that stem cells were elusive in adult lungs. There was debate about whether they even existed, but it now seems fairly established that there are some of the little guys in there. Just because one of the …

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