MSCs Mesenchymal stem stromal cells

MSCs or Mesenchymal stem and stromal cells are an important kind of multipotent adult stem and progenitor cell. It’s increasingly being realized that MSCs as typically prepped often contain a heterogeneous mix of cells including stromal cells that are supportive in nature and are not stem cells.

What is Wharton’s jelly & its possible clinical uses?

Wharton's jelly umbilical cord H&E

For more than a year in my first job as a scientist I isolated cells from umbilical cord veins and then tossed the tissue away, never realizing there was more there that could be useful in the form of something called Wharton’s jelly. What’s in this article Umbilical cord histology & Wharton’s jelly | What …

What is Wharton’s jelly & its possible clinical uses? Read More »

What are adult stem cells & their clinical applications?

mesenchymal cells

When someone uses the term “adult stem cells” you might think that simply means stem cells from adults. However, it’s not that simple. The goal of today’s post is to help you get all the key facts about adult stem cells. This includes the different types of adult stem cells and their clinical potential. What …

What are adult stem cells & their clinical applications? Read More »

Mesenchymal cells or MSCs: definition, stem cell fraction, & trial map

mesenchymal cells, MSCs, mesenchymal stem cells

I confess that I’m old enough to remember when the acronym MSC stood unambiguously for “mesenchymal stem cells”, but should it refer to a broader term like “mesenchymal cells”? The field has moved in that direction. I think that’s the best way to go too and I’ll explain why. The goal of today’s post is …

Mesenchymal cells or MSCs: definition, stem cell fraction, & trial map Read More »

Small umbilical cord stem cell COVID-19 trial: sign of efficacy?

Cord-blood-autism

A new paper today in Stem Cells Translational Medicine on a small COVID-19 Phase 1/2a trial using an umbilical cord stem cell product reports a surprising degree of possible efficacy. What’s the scoop here and could there be some hype in the media about this new study such as one of the authors describing the …

Small umbilical cord stem cell COVID-19 trial: sign of efficacy? Read More »

Recommended reads: MSCs, vision, endothelial cells, more

wang et al 2020 science advances

What a year 2020 was, but there was still plenty of great science, which continues now in 2021 including published research like today’s recommended pieces and there’s one thread on MSCs today. The Niche new look, more features, and a Medical Advisory Board for 2021 Before we get to the recommended reads, note that 2021 …

Recommended reads: MSCs, vision, endothelial cells, more Read More »

Weekend cell biology reads: Mesoblast COVID-19 deal, pubs

bergert cell stem cell 2020 cell mechanics sm

The COVID-19 pandemic is tearing through the country right as we are starting into the holiday season, but the wheels of science including cell biology keep going and we keep reading all the great work. What news or papers caught your eye? Here are some of the things I have on my list of reading. …

Weekend cell biology reads: Mesoblast COVID-19 deal, pubs Read More »

Mesoblast MSCs Quell Peds GvHD; On Road to FDA Approval?

MSCs-mesenchymal-stem-cells-stromal-cells-small

Graft-versus-host disease (GVHD) is counterintuitive In the weeks and months following a transplant, a major concern is the recipient’s immune system rejecting the “foreign” biological material. But in GVHD, the opposite happens: transplanted tissue unleashes a horde of T cells that spark a cascade of inflammation, within 100 days. Typically, GVHD follows a bone marrow …

Mesoblast MSCs Quell Peds GvHD; On Road to FDA Approval? Read More »

Overselling stem cells for COVID-19: WSJ article & UMN PR

EM-of-Novel-Coronavirus-SARS-CoV-2-that-causes-COVID-19

Many are  jumping on the bandwagon of trying stem cells for COVID-19 or testing other cellular therapies for the novel coronavirus disease, but there have been problems with either the rationales for the trials themselves or more often with how they portrayed. Sometimes there has even been outright hype. I’ve called this collective trend of …

Overselling stem cells for COVID-19: WSJ article & UMN PR Read More »

Recommended reads: COVID-19 updates, FDA stem cell nod, PRC2, more

Fig.-3d-Rai-et-al-Nature-Communications-2020

Today’s post is the latest edition of my weekly recommended reads, which this week include Fate Therapeutics, COVID-19 updates, AAMC, and more including some great pubs such as one on 2 modes of PRC2 function. Also check out this handy resource: Helpful 2020 List of Stem Cell Journals and this blast from the past post of 10 …

Recommended reads: COVID-19 updates, FDA stem cell nod, PRC2, more Read More »

Weekly reads: FDA news, goosebump stem cells, MSCs, autophagy

Levy-et-al-MSCs-Science-Advances

Ready for the latest recommended weekly reads in the world of stem cells and the regenerative medicine space including a bunch of important new FDA posts & changes? This post has quite a lot on the FDA since it had a very big week with several new items of major importance to the cellular and regenerative …

Weekly reads: FDA news, goosebump stem cells, MSCs, autophagy Read More »