Weekly Reads

The Niche’s recommended Weekly Reads on stem cell research and regenerative medicine.

Recommended reads: MSC analysis points to challenges, IPSC NKs kill liver cancer, turning white fat into brown

MSC single cell transcriptome, MSC

Mesenchymal stromal/stem cells or MSCs are widely used by unproven clinics, but MSC research also suggests real promise in specific areas. Clinics mainly use adipose MSCs (often called SVF) or bone marrow MSCs. However, umbilical cord MSC preparations are getting more popular too. Many questions swirl around the use of MSCs including what exactly are […]

Recommended reads: MSC analysis points to challenges, IPSC NKs kill liver cancer, turning white fat into brown Read More »

Recommended reads: flesh-faced robots, ALS, Spina Bifida,neuronal CRISPR

flesh-faced robots

Combinations of human flesh and robots are more in the news lately. Sometimes the fleshy parts are grown from stem cells in a lab. Robots with fleshy faces Scientists in Japan Give Robots a Fleshy Face and a Smile, NYT. I’m working on a piece about robots in China with small, human brain-like structures. Stay tuned

Recommended reads: flesh-faced robots, ALS, Spina Bifida,neuronal CRISPR Read More »

Recommended reads: Shinya interview, MYC-MAX & extra digits, microglia as a therapy, oocyte maintenance

N-myc, heterochromatin

The proto-oncogene MYC is one of those factors studied in thousands of papers. MYC and its dimerize partner MAX are also seemingly involved in just about everything. They have crucial roles in many kinds of stem cells including adult and embryonic stem cells. One way or another MYC induction seems very helpful for cellular reprogramming

Recommended reads: Shinya interview, MYC-MAX & extra digits, microglia as a therapy, oocyte maintenance Read More »

Recommended reads: Nature Catherine Verfaillie retraction, Horvath paper, Vertex

Catherine Verfaillie retraction, Catherine Verfaillie

When I was first really getting into stem cells as a trainee the name Catherine Verfaillie came up as a scientist to watch in the adult stem cell area. It wasn’t too long after that though that I started hearing that some of the work from her lab at the University of Minnesota was being

Recommended reads: Nature Catherine Verfaillie retraction, Horvath paper, Vertex Read More »

Recommended reads: gov scientists fear Trump 2nd term, MYCT1 in HSCs, in vivo editing

Trump

I’ve only met one scientist who was openly a Trump fan, but I’m sure there are more out there. Still, it seems most scientists are no fans of the former president. A new WaPo piece highlights how federal scientists are worrying about a possible second term for the former president. Government scientists & a second

Recommended reads: gov scientists fear Trump 2nd term, MYCT1 in HSCs, in vivo editing Read More »

Recommended reads: FDA warning on stem cells for pets, chromatin, aging & HSCs

Safari Stem Cell, stem cells for pets

When I first saw the new FDA warning on stem cells for pets and the logo for the company that received it, I was surprised in a few ways. I don’t recall ever seeing such a letter and the logo is something else. We’ll get into all of that in a moment, but first, since

Recommended reads: FDA warning on stem cells for pets, chromatin, aging & HSCs Read More »

Weekly reads: diabetes, GvHD, Novo Nordisk & regenerative medicine, HDACs

mesenchymal cells

Do many in the regenerative medicine field have favorite types of stem cells? Some seem to think there’s a tension between those working on pluripotent stem cells like iPS cells and those working with MSCs. I don’t see it that way, though. Whatever stem cells work best for a particular condition should be used and,

Weekly reads: diabetes, GvHD, Novo Nordisk & regenerative medicine, HDACs Read More »

Recommend reads: FDA SVF warning, big Aspen grant, CSI finale invokes stem cells

SVF

One of the most contentious areas in the regenerative medicine arena is whether a fat tissue product called stromal vascular fraction or SVF is a drug. The FDA says SVF, even in autologous form, is a drug. It is seeking an injunction against a California-based network of SVF clinics but lost the initial case. That

Recommend reads: FDA SVF warning, big Aspen grant, CSI finale invokes stem cells Read More »

Recommended reads: CAR-T for Lupus, CRISPR vision, journal closures

CAR-T for Lupus

Can researchers use CAR-T for lupus? It’s always exciting when one’s home institution has an interesting new therapy in development.  Here at UC Davis Health, there has been an increasing stream of such encouraging trials in the pipeline. I’ve written before about the promising trial of stem cells for spina bifida. Now there’s news related

Recommended reads: CAR-T for Lupus, CRISPR vision, journal closures Read More »

Recommended reads: 3 infected in Mexico, stem cell hype, hearing restoration

muscle stem cell hype

Stem cell hype is a big problem these days. It’s been going on for decades. Even some generally good citizens of the stem cell and regenerative medicine arena engage in it at times. Maybe a few of them don’t even realize what they are doing. I think a few journalists occasionally fall into the hype

Recommended reads: 3 infected in Mexico, stem cell hype, hearing restoration Read More »