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‘I’d need a drink’: WaPo deep dive on clinic firm Lung Health Institute

December 7, 2019 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Washington Post reporters William Wan and Laurie McGinley have a new piece on the unproven regenerative clinic firm the Lung Health Institute. This article has a number of surprises and new insights. Previously the Lung Health Institute was called just the Lung Institute. It was recently acquired by the publicly-traded company H-CYTE, stock symbol HCYT. In the […]

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Whatever happened to the STAP cell scientists including Haruko Obokata?

November 14, 2019 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Once upon a time this blog and major outlets around the world were regularly writing about a Japanese stem cell researcher named Haruko Obokata (小保方晴子). Whatever happened to Obokata and the other folks directly involved in STAP cell research? First, a bit of background because maybe still a few people never heard of STAP cells

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Unnatural Selection review: captivating mind-bender but needed more science

October 28, 2019 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Unnatural-Selection-with-patient-Jackson-Kennedy

Today’s post is a review of Unnatural Selection, the new Netflix science docuseries focused on CRISPR and other disruptive genetic and reproductive technologies. The show is an interesting mix of personalities and stories from patients, scientists, biohackers, and more. One patient thread is the story of a wonderful little boy named Jackson Kennedy. He wants

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Right To Try law has a big loophole that’s an opening for bad actors

October 7, 2019 / Professor Paul Knoepfler, Ph.D. / 14 Comments

There appears to be a big, risky loophole in the relatively new national Right To Try law. Some folks apparently anticipated this problem long ago, but I think most of us weren’t aware of it. Update: More specifically, some law and policy experts were writing about this and other potential loopholes in 2018. I recommend

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ViaCyte Q&A: CRISPR Tx quick progress, ongoing diabetes trial, & more

September 25, 2019 / Professor Paul Knoepfler, Ph.D. / 9 Comments

ViaCyte is one of the most exciting stem cell and regenerative medicine biotech companies so I like to try to check in with them regularly. Today’s post is my new interview with ViaCyte leader Paul Laikind on recent developments. We had a great chat about the science and how things are looking upbeat for the

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Jeanne Loring: hES cell research, Bush, & her career

August 9, 2019 / Professor Paul Knoepfler, Ph.D. / 33 Comments

By Jeanne Loring A stem cell anniversary: 18 years ago today that the US initiated funding of human embryonic stem cell research. August 9, 2001 was a big day for me. George W. Bush was the US president, and it was an understatement to say that I was not very fond of his policies; but

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What is stromal vascular fraction or SVF?

July 21, 2019 / Professor Paul Knoepfler, Ph.D. / 26 Comments

When people discuss “fat stem cells” they usually mean “stromal vascular fraction” or SVF. While references to fat or adipose stem cells can sometimes mean non-SVF materials, these days adipose SVF gets the most attention. But, does anyone have a clear picture of this biologic? Fortunately, it’s starting to come more into focus in recent years

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Asilomar: great science plus shells, flowers on the beach

May 12, 2019 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Asilomar is known in the field of biomedical sciences as a great place to go for small meetings. I was there recently for the First Annual Bay Area Stem Cell Conference, which I helped to organize. It was an exciting meeting and all the presenters (except keynoters) were trainees. The amount of great stem cell

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Sexual Medicine Society on Unproven Regenerative Therapies for Erectile Dysfunction

April 10, 2019 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Sexual-Medicine-Society-of-North-America

There are many potential causes of erectile dysfunction or ED and a host of ideas about how to treat it. Some approaches to erectile dysfunction are evidence-based and even have been rigorously proven such as the drugs Viagra and Cialis, which increase blood flow to the penis. Depending on the causes of the dysfunction, these

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Perspectives: FDA warns umbilical firm & continues stream of “mini-warning” letters

April 4, 2019 / Professor Paul Knoepfler, Ph.D. / 1 Comment

umbilical-cord-blood, umbilical cord blood stem cells

Yesterday we learned that the FDA issued a warning letter to the cord stem cell firm, Cord for Life. In this warning, the FDA indicated that the firm’s product is actually a drug product and lacks necessary pre-market approvals. In addition, the agency highlighted apparent deviations from CGMP practices. The most important part of the

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