A small group of the STAP authors via RIKEN have now released a detailed protocol also available at Nature Protocol Exchange for making STAP stem cells entitled “Essential technical tips for STAP cell conversion culture from somatic cells”. This comes about 5 weeks after publication of their Nature STAP stem cell papers. 2020 update: With the 4th and […]
Reactions to RIKEN’s STAP cell protocol Read More »
What’s the latest surprise on the STAP cell front? There have been many unexpected turn along the way in the past few weeks of the rollercoaster ride the stem cell field is on related to STAP stem cells, the super powerful stem cells reportedly (in two papers in Nature) made “simply” by exposing cells to
Nature Post-Pub Examination of Its Own STAP Cell Papers Breaks New Ground Read More »
If you’ve been paying attention to the stem cell world, you’ll remember Woo Suk Hwang, who nearly derailed the future of stem cell research by very publically proclaiming that he had made human embryonic stem cells by somatic cell nuclear transfer (SCNT). No, this has nothing to do with Shoukhrat Mitalipov’s report of successful generation
Jeanne Loring on Woo Suk Hwang Approved Patent of SCNT ESCs Read More »
What does the future hold for CIRM? I asked former CIRM Board Chair and Prop 71 leader, Robert Klein, about that and more in the interview below. He also says some particularly exciting clinical trial and other developments in the stem cell field are coming soon. What got you excited for the very first time
Interview with Robert Klein on CIRM’s Future Read More »
What are Splashy Papers in science? I spend some hours each week reading and thinking about the recent scientific literature and I’m sure many of you do the same thing, but do we gravitate towards hyped “holy crap” papers? Every so often, a new paper erupts on the scene. It makes a big splash with
The ‘Holy Crap’ Effect: Reflecting on Splashy Papers Read More »
2014 Epigenetic mechanisms of tumorigenicity manifesting in stem cells. Tung PY, Knoepfler PS. Oncogene. Jun 16;0. doi: 10.1038/onc.2014.172. [Epub ahead of print] Histone H3.3 regulates dynamic chromatin states during spermatogenesis. Yuen BT, Bush KM, Barrilleaux BL, Cotterman R, Knoepfler PS. Development. 2014 Aug 19. pii: dev.106450. [Epub ahead of print] Miz-1 Activates Gene Expression via a Novel Consensus DNA Binding Motif..
Knoepfler Lab Publications Read More »
CIRM, the California Stem Cell Agency, is looking for a new President since current President Alan Trounson announced that he will be moving on at some point in the near future. CIRM itself is undergoing changes as it anticipates a key turning point in 2017 when it will not have state funding from Prop 71
More on CIRM’s Search for a New President Read More »
By Jeanne Loring “Shared Labs Axed” was the headline for David Jensen’s blog about the California Institute for Regenerative Medicine, the funding agency founded after voters approved Proposition 71, the “stem cell research and cures” initiative. I was there when the ax fell, in Los Angeles at the meeting of CIRM’s governing board, along with
Guest Post By Jeanne Loring: Efforts to Save CIRM Shared Labs Read More »
The Knoepfler Lab conducts stem and cancer cell as well as chromatin/epigenetics research at the UC Davis School of Medicine. Our team has two big picture goals: (1) catalyzing the development of more effective treatments for cancers based on targeting stem cell-related machinery in tumorigenesis and (2) producing safer stem cell-based regenerative medicine therapies. We are particularly
A big, fat elephant in “the room” of the commercial stem cell field today is something called stromal vascular fraction or SVF, made from human fat tissue or adipose. If you care at all about stem cells or the stem cell field more generally, you had better educate yourself on SVF. You can learn a
Law and Order SVF: what is stromal vascular fraction? Read More »