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The dangers of stem cell self-experimentation: cartoon & discussion

February 25, 2013 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 8 Comments

A concerning trend in the for-profit stem cell field, but one that does not get enough attention, is self-experimentation by those selling (often unlicensed) stem cell treatments. In other words, the stem cell clinic leaders and docs often not only sell stem cell treatments to patients, but also they give themselves the same treatments, often repeatedly. …

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Media’s crazy cocktails on cancer: today’s case of whole milk and soda

December 1, 2012 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

Yesterday was my 3-year anniversary of surgery for prostate cancer. I’m doing great in long-term remission and hopeful it stays that way. You never know. Knock on wood. Over the years, as both a cancer researcher and patient, I’ve found myself frustrated with the way the media fails at reporting on supposed risky behaviors for …

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Review of the new Zaret Cell paper on Myc & OSK in cellular reprogramming

November 29, 2012 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

There’s a new paper out this week in Cell from the Zaret lab that is very exciting. In this manuscript, Facilitators and Impediments of the Pluripotency Reprogramming Factors’ Initial Engagement with the Genome, Zaret’s team explores how Myc and Oct4, Sox2, and Klf4 (OSK) behave at the genomic level during cellular reprogramming. What are the most …

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8 simple reasons not to get an unlicensed stem cell treatment part 2: lack of follow-up

November 15, 2012 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

I’m doing a series of posts on straightforward reasons why patients should not get unlicensed stem cell treatments. Part 1 of the series was on the risk of losing medical insurance coverage. Today is part 2, which is focused on a serious failing of many for-profit, point-of-care stem cell clinics selling unlicensed treatments: lack of …

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Thoughts on prostate cancer…3 years out

November 12, 2012 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 8 Comments

Three years ago I found myself in a tough spot to put it mildly with a prostate cancer diagnosis at age 42. In October 2009 I had a mildly elevated PSA test result (see more on that below) leading to a prostate biopsy. At the end of that month I had just received the news …

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Money and stem cell ‘miracles’: Pluristem questioned on ethics

November 8, 2012 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

Pluristem Therapeutics Inc. is a publicly traded (NASDAQ) biotech Israeli company that is developing stem cell treatments based on the use of expanded placental stem cells called PLX cells. The Pluristem PLX drug is not approved for treating patients at this time in any country, however Pluristem has treated a handful of patients via something …

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David Granovsky of ‘The Stem Cell Blog’ disrespects Christopher Reeve

September 26, 2012 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

There aren’t that many stem cell blogs out there on the Internet, although the number is growing, and the one that has been around quite a while is called “Repairstemcell” or “The Stem Cell Blog”. Granovsky is a self-proclaimed empowerer of patients and calls himself “the informer”, apparently meaning someone who will guide patients to …

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Alienable: how personifying corporations & zygotes robs real people of their rights

September 13, 2012 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

In the U.S. Declaration of Independence three “inalienable rights” are said to be endowed on people: life, liberty, and the pursuit of happiness. People also have other rights in the U.S. including freedom of speech and religion. These rights seem clear enough, but wait a minute….what are “people”? What entity qualifies as a “person” to …

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Caloric restriction: dieting monkeys teach human scientists?

August 30, 2012 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 7 Comments

The notion of caloric restriction (CR) as a means to prolong human life is intriguing. The basic idea of CR is that if you eat a lot less than the average person you’ll live longer. You might even live a higher quality, healthier life. But is this true? (update: see my newer post on 5 …

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All that scientists failed to learn in kindergarten: a humorous look at origins of social ineptness

August 22, 2012 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

Why are some scientists so inept socially and end up in struggles interacting with other people? Kindergarten! Yes, my theory is that many of the key events are traceable to kindergarten and more specifically to what future scientists failed to learn then even if they technically passed the class and moved on to first grade. …

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