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Gaetan Burgio New Data & Theory on NgAgo versus CRISPR

July 31, 2016 / Professor Paul Knoepfler, Ph.D. / 3 Comments

By Gaetan Burgio CRISPR/Cas9 genome editing has dramatically changed our way to perform biological experiments. While highly efficient and easy to use, one limitation with CRISPR/Cas9 mediated genome editing technology is the occurrence of off-target effects and the restriction of the PAM recognition sequence. Many modifications from the original system have been proposed to improve […]

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UK should freeze mitochondrial replacement as Egli paper ID’s serious problem

May 19, 2016 / Professor Paul Knoepfler, Ph.D. / 1 Comment

An important new Cell Stem Cell paper from Dieter Egli’s lab points to an inherent, serious problem with so-called 3-person IVF or mitochondrial replacement technology that warrants putting an immediate hold on all efforts to use it in humans. I have pasted the graphical abstract from the paper below. For years a few of us scientists and

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Paris human gene editing workshop summary

April 29, 2016 / Professor Paul Knoepfler, Ph.D.

Editors note: This is a guest post from Caroline Simons who is attending the two Paris meetings on human gene editing. For more background on those meetings see here. By Caroline Simons There were just over a hundred participants at the workshop organized by the Federation of European Academies of Medicine, the UK Academy of

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How did my 20 stem cell predictions for 2015 fare?

December 17, 2015 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Each year around this time I check up on my past year’s predictions for the stem cell field. For 2015 I made 20 predictions. You can see past 10 predictions lists for 2013 and 2014. It’s pretty interesting to look back at where the focus was in past years and what my crystal ball yielded

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World Stem Cell Summit 2015: IPS cells, #CRISPR, CAR-T

December 11, 2015 / Professor Paul Knoepfler, Ph.D. / 4 Comments

It’s been a great couple days so far here at the World Stem Cell Summit in Atlanta. You can follow it on Twitter using the #WSCS15 hash tag. I first attended it 5 years ago in Pasadena. One of the special aspects of WSCS is it brings together diverse stakeholders in a way that just

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Live Blogging #GeneEditSummit Day 1 Post #2: State of the Science, #CRISPR

December 1, 2015 / Professor Paul Knoepfler, Ph.D. / 3 Comments

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Now we hear from the scientists on the front lines of CRISPR, covered in this post #2 of the Human Gene Editing Meeting. You can read Post #1 here. Jennifer Doudna starts off the big human gene editing science session on the current state of the human gene editing science and CRISPR. She gave an

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Knoepfler Lab 2015: Our mission and research

September 15, 2015 / Professor Paul Knoepfler, Ph.D.

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Many of this blog’s readers ask about my own lab’s research: what is the focus of the work in the Knoepfler Lab? You can go check out our lab website, but I thought it might be time again to blog about what we are all about as a lab and what we have been up

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How are my 20 stem cell predictions for 2015 doing?

June 30, 2015 / Professor Paul Knoepfler, Ph.D. / 9 Comments

Each year towards the end of December I make predictions for the coming year as I did for 2015. In the past I usually make a top 10 prediction list, but for this year I made 20 predictions. Admittedly some of them may have been more hopes than predictions. At mid-year today on June 30th,

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250,000-fold oversight on 3-person IVF mitochondrial transfer?

June 23, 2015 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Remember the debate over so-called 3-person IVF? The goal of this technology, also referred to as mitochondrial transfer and 3-parent IVF, is to prevent mitochondrial disease through nuclear transfer in oocytes or one-cell embryos. The resulting genetically modified (GM) human embryos and ultimately children if it works could have dodged mitochondrial disease, but also could have serious or

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Guest Post by Chris Scott–The Great CRISPR Controversy: What’s Next?

May 20, 2015 / Chris Scott / 1 Comment

A decade ago I wrote an article in the journal Nature Biotechnology about the rise of a new gene editing technology called zinc finger nucleases (ZNF). It was one of those “drumbeat” discoveries: at the time, my sense was it would revolutionize how we deliver genes to cells and tissues, and profoundly change the way

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