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Biotechnology & the Ethical Imagination – A Preview of BEINGS summit

May 4, 2015 / Aaron Levine

Later this May, I will attend and participate in Biotechnology and the Ethical Imagination (BEINGS 2015). This is an exciting and experimental summit that will focus on advances in cellular biotechnology – including both stem cell science and synthetic biology. The meeting is premised on the idea that the implications of increasing biotechnology power are […]

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‘Roundup Ready’ Humans?

April 28, 2015 / Professor Paul Knoepfler, Ph.D. / 3 Comments

‘Roundup Ready’ Humans? What the heck does that mean? One of my favorite parts of doing a blog is getting reader comments. It definitely makes the blogging experience more fun and keeps me on my toes. I also learn a lot. The more discussion there is, the better. One of the most frequent commenters is

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4 areas of debate on 1st human embryo genetic modification paper

April 27, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Last week was a big one for the life sciences in that we saw the milestone of the first ever published paper reporting human embryo genetic modification (see here and here). It was one of those situations where we knew it was coming, but it was still a jolt. Not surprisingly this event sparked intense discussion

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The big blind spot on CRISPR for human embryo editing: PGD

April 24, 2015 / Professor Paul Knoepfler, Ph.D. / 10 Comments

There is a big old blind spot in the discussion over germline gene editing in humans: preimplantation genetic diagnosis (PGD). There’s been a lot of talk in 2015 about worries over how gene editing technology such as CRISPR might be used prematurely in the clinic in an unsafe or unethical manner in humans in the

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Interview with Bioheart CSO, Kristin Comella including on FDA

April 21, 2015 / Professor Paul Knoepfler, Ph.D. / 13 Comments

I invited the Chief Scientific Officer (CSO) of Bioheart, Kristin Comella, to do an interview after hearing some buzz that this could be a critical time for the company and that it might have been recently visited by the FDA. Note that Comella not just Bioheart CSO, but also the primary instructor for physician training in stem

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Doctors call for Dr. Oz to be booted from Columbia

April 17, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Controversial TV physician Dr. Mehmet Oz hasn’t had a great year what with his disastrous testimony before Congress. (2020 Update; Dr. Oz recently had a good show on stem cell clinics so that’s something. I discussed issues with his staff prior to the show.) Now Dr. Oz has been slammed by a group doctors from

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Jennifer Doudna Interview on CRISPR, Human Gene Editing

April 14, 2015 / Professor Paul Knoepfler, Ph.D.

I’m doing a series of interviews with leaders in the field on human germline modification with the first interview in this series with George Church and today’s second in this series is a conversation I had with Dr. Jennifer Doudna, a pioneer in CRISPR-Cas9 technology. Doudna is a Professor in MCB and Chemistry as well

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Hank Greely Human Germline Modification Post

April 10, 2015 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Hank Greely over at The Center for Law and Biosciences at Stanford Law School was one of the participants in the recent Napa meeting on approaches to human germline genetic modification. Hank was also one of the authors on the resulting position paper in Science with David Baltimore as first author (here). Now Hank, pictured below,

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Rumors flying on human embryo editing papers

April 9, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

We’ve all heard the human embryo editing rumors. There is a sense that human embryos have already been CRISPR’d. Rumors are rumors and they may mean not a whole lot, but there definitely is a huge buzz on this right now both in a positive sense and with concern. The excitement is over the power of

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5 new cool papers on CRISPR Cas9 gene editing

April 8, 2015 / Professor Paul Knoepfler, Ph.D.

CRISPR Cas9 is a relatively new, powerful approach to gene editing and genetic modification more generally. In the relatively short window of time in which this technology has been widely available for gene editing applications it has already evolved rapidly to become more powerful. Here are some new papers of interest on this technology. With

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