The mesenchymal stem cell (MSC). So important and yet so misunderstood? People pronounce it in different ways. People isolate the MSCs in different ways. Each person’s MSCs are very different. Each lab’s MSCs are different. (see picture above of MSCs showing fibroblastic morphology; source is Wikipedia) Someone once told me that MSCs are the same […]
Would an MSC by any other name still smell as sweet? Read More »
The field of induced pluripotent stem cells (iPSC) has really shaken up science over the last half dozen years reversing our notion that differentiated cells are stuck in that fate, when in reality they are plastic and can “turn back the clock” to become embryonic stem cell-like cells. Now we have an iPSC paper in Nature,
Surprising human genomic mosaicism means not all your cells have the same DNA Read More »
My lab just published a somewhat provocative paper (still in unproofed form at this point) arguing that iPS cells are very similar in some ways to cancer cells. How did we get to that conclusion (discussed in this post today, part 1 of the story) and what’s the back story on this paper (discussed in a later
iPS cells are similar to cancer cells: part 1 of discussion of new paper Read More »
Is it worth it to do stem cell banking? When I was a kid I remember hearing about people having themselves frozen or even just their heads frozen shortly after death. The idea was to cheat mortality by preserving oneself or critical parts of oneself until some future date when scientists and doctors would have
Cryogenics to stem cell banking: time for deposit? Read More »
I’m enjoying Celltex’s new website and I’m appreciative of their great responsiveness to my questions. Transparency is a beautiful thing! My latest question to them was whether they, given that the FDA called them a “drug manufacturer”, are now planning to or have already filed an IND. An IND is an application for an investigational
More Celltex Q&A: we are not a drug manufacturer Read More »
What if I told you I believe that iPS cells really began in Seattle in the 1980s? Call me crazy? Read on. We hear a lot about how iPS cells were first created in 2006 in Japan by Shinya Yamanaka. I often say this myself. However, as is the case with so much in science,
How iPS cells germinated in part in Seattle in the 1980s Read More »
What are the most important iPS cell papers so far? 1) Yamanaka’s first paper on mouse iPS cells. Revolutionary. Intriguing perspectives presented in day 1 of the iPS cell field. Interesting statements such as Myc is required. Also take a look at those other reprogramming factors that he tested…there’s a tremendous amount there, largely unexamined.
What are the best iPS cell papers so far? Read More »
The leading cause of death in America and many other countries of the world is cardiovascular disease (CVD) including heart attacks and strokes. In fact, CVD kills and disables more people than most often top killers combined including cancer. The myth that CVD is a “man’s disease” only makes the situation worse as in reality CVD
Transdifferentiation meets gene therapy to tackle heart disease Read More »
Interestingly, the Komen Foundation appears open to funding human embryonic stem cell (hESC) research. The latest report from Science includes a quote from Komen that denies any changes in funding policy for research and suggests they have not ruled out funding such research: Contrary to circulating online reports, Komen has not “de-funded” any grantee based on human embryonic stem
Komen Foundation open to funding human embryonic stem cell research Read More »
Do we still need iPS cells if transdifferentiation is so cool? Wait, how did we get to the point that people are asking me that extreme question? When iPS cells were first introduced to the world by Shinya Yamanaka, who I think will win the Nobel Prize sometime in the next few years, some folks went
Transdifferentiation does not make iPS cells obsolete Read More »