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Weekly reads: R01 grant trends, DPPA4, adult human neurogenesis debate

NIH R01 grant trends

Great ideas and talented scientists are not enough as biomedical research needs funding and here in the U.S. that means having R01 grant success. The trends since 1995 are slowly heading the wrong way. The average age of getting your first R01 grant keeps getting older. There is also still a bit of a possible …

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Why De-extinction of Woolly Mammoths is Still a Bad Idea

George Church De Extinction Mammoth

The push for de-extinction of woolly mammoths is a perfect example of when one notion can be both fun and a rotten idea. You can’t let the coolness push you down a bad path. You can see my new YouTube video covering the main points of this post from our YouTube channel further down. Please …

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Authors on The Niche

Paul-Knoepfler

The Niche has had many authors over the years, focusing on expertise in the biomedical arena and in particular related to stem cells. I’ve invited many authorities in particular areas to write posts. Over the years I’ve written probably 99+% of the posts here on The Niche, but we’ve also had some great guest authors …

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Can clinic biz US Stem reboot after losing suit? Its email to customers & more

USRM-clinic-email

The unproven stem cell clinic firm US Stem Cell Inc. is in a world of hurt. If a federal judge says you can no longer sell your key commercial offering, how do you survive as a company? US Stem probably has been thinking about that possibility for months. Still, it’s not yet clear where the …

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Groundbreaking defeat for US Stem Cell, fat stem cell clinic industry in federal court

us-stem-cell-clinic

In a precedent-setting decision, a federal court has ruled for the FDA against a key stem cell clinic firm called U.S. Stem Cell, Inc. The court granted summary judgment for the FDA in its suit seeking a permanent injunction against the Florida stem cell clinic firm. While the company is likely going to appeal, this is …

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Does stem cell clinic IRB approval mean much? Insights from blinding cases

stem-cells-eyes, stem cell therapy side effects.

Could the blinding of three women at a stem cell clinic have been prevented by better oversight or was the clinic acting outside of the scope of oversight by its institutional review board (IRB)? More broadly, when is an IRB conducting proper oversight and how do we know? When on the other hand is it …

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Negative stem cell clinic outcomes include 3 blinded women

Michael-Miller-MD-PhD-e1473364751156

What can go wrong with unapproved stem cell clinic offerings? The answer including from presentations at the FDA today turns out to be very serious, negative results right here in the U.S. Thomas Albini, MD gave a talk entitled,  “Severe Visual Loss After Intravitreal Injection of Autologous Adipose Tissue-derived Stem Cells for Age-related Macular Degeneration”. …

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Yamanaka’s baby turns 10: ten IPS cell hot button bullet points

Nobel Laureate Shinya Yamanaka, the first to produce induced pluripotent stem cells

Has it really been 10 years since induced pluripotent stem cells (aka IPS cells or IPSC) came onto the scene in the stem cell field? Yes, it was a decade ago that now Nobel Laureate Shinya Yamanaka (山中伸弥) published that seminal Cell paper on reprogramming to make mouse IPS cells and then human IPS cells …

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Stem cell field in mourning: Paolo Bianco dies at 60

Paolo-Bianco

Paolo Bianco reportedly has died at age 60. This is terribly sad news and a huge loss for the stem cell community. Paolo made great contributions both in the science of stem cells itself and also in the area of advocating for responsible science. It is challenging to do both and he did it incredibly …

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