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UK should freeze mitochondrial replacement as Egli paper ID’s serious problem

May 19, 2016 / Professor Paul Knoepfler, Ph.D. / 1 Comment

An important new Cell Stem Cell paper from Dieter Egli’s lab points to an inherent, serious problem with so-called 3-person IVF or mitochondrial replacement technology that warrants putting an immediate hold on all efforts to use it in humans. I have pasted the graphical abstract from the paper below. For years a few of us scientists and […]

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In Depth Report from April 29th Paris Human Gene Edit Meeting

May 11, 2016 / Professor Paul Knoepfler, Ph.D.

Editor’s note. Caroline Simons attended both the April 28th (see her report on that here) and 29th Paris meetings on human gene editing/genetic modification. Today, we have her in depth report on the April 29th meeting. I have posted her piece in full with only minor edits. If you are in a rush you can

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Paris human gene editing workshop summary

April 29, 2016 / Professor Paul Knoepfler, Ph.D.

Editors note: This is a guest post from Caroline Simons who is attending the two Paris meetings on human gene editing. For more background on those meetings see here. By Caroline Simons There were just over a hundred participants at the workshop organized by the Federation of European Academies of Medicine, the UK Academy of

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George Church chat: CRISPR people, Zika, weapons

April 18, 2016 / Professor Paul Knoepfler, Ph.D. / 4 Comments

I talked last year about human genetic modification by CRISPR with George Church a year ago. Now we’ve followed up with a long chat on this topic going into much more detail and with questions on recent developments. Each question is listed numerically and then there is a back and forth on that question with George

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Poll: How do you feel about ‘pay-to-play’ clinical trials?

March 30, 2016 / Professor Paul Knoepfler, Ph.D. / 15 Comments

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There’s a growing trend whereby patients have to pay to be in a clinical trial. This is now widely referred to as “pay-to-play”. Proponents of this idea point toward potential benefits in the form of patients gaining access to innovative therapies. They also argue that this approach provides a much-needed funding mechanism for the trials

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ViaCyte on the Rise: First Diabetes Trial Data & Acquires BetaLogics IP

February 4, 2016 / Professor Paul Knoepfler, Ph.D.

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Clinical research on Type I Diabetes is one of the most exciting and promising areas of stem cells and regenerative medicine for human disease. Two of the coolest companies out there in this arena have been ViaCyte and BetaLogics (owned by J&J). For more on ViaCyte see my interview with President and CEO Paul Laikind

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NAS proposes prudent US policy on 3-person IVF

February 3, 2016 / Professor Paul Knoepfler, Ph.D. / 3 Comments

A new report from the National Academies of Sciences (NAS), Engineering, and Medicine here in the US recommends a policy significantly more cautious on first read for 3-person IVF than that in place now in the UK. My initial take on this new 164-page report is that it is very well thought out and the

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Tick Tock Genetic Clock: How soon until first DIY CRISPR of self?

October 15, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

I just did a blog post today on the striking story of someone doing DIY CRISPR gene therapy on themselves. A question came to mind. How long until someone does a DIY attempt to CRISPR themselves? In the DIY gene therapy story, the person was injected with so-called “gain-of-function” viruses to try to reap health

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Steven Pinker interview: case against bioethocrats & CRISPR germline ban

August 10, 2015 / Professor Paul Knoepfler, Ph.D. / 15 Comments

CRISPR-Cas9 gene editing technology is red-hot right now and I’ve been doing interviews with various thought leaders on it, which today includes Steven Pinker. This technology has great power for research in the lab and there are hypothetical transformative clinical applications of CRISPR too. The latter efforts could include experimental attempts at reversal of disease-causing

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Perspectives on Planned Parenthood Fetal Tissue Video

July 20, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

You probably have heard by now about the controversial video (below) showing the senior director of medical services of Planned Parenthood, Deborah Nucatola, discussing the procurement and distribution of fetal tissues from abortions for research. The film was taken secretly using a hidden camera by anti-abortion activists who concealed their real identities. It was edited

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