As a stem cell scientist I hear all the time about how the pipeline from the lab to the clinic is incredibly slow and terribly inefficient. Meanwhile millions of people have conditions that the current state-of-the-art medicine cannot effectively treat. Somehow we need to make a fundamental change to improve this process. I think one […]
Big tent team science: new ideas about clinical trials Read More »
It has been a week to think about mentors and I posted somewhat autobiographically on how to find and be a good mentor a few days ago. Also along these lines, I asked one of the great mentors of all time, Irv Weissman, about his early career and who were the mentors that made the
There is a kind of invisible cultural wall between patients such as cancer patients and biomedical scientists like me, but this wall does not have to exist and indeed it is a negative wall as patients, scientists, doctors, agencies, and advocates can achieve far more together than apart. But the wall is surprisingly strong. Last
My Cancer: how I became an advocate too Read More »
The FDA has given Advanced Cell Technology (ACT) the go ahead to begin their clinical trial using retinal progenitor cells derived from hESC by clearing the company’s IND application, bringing hope to those with vision loss and even blindness. The trial will be a combined Phase I/II to treat Stargardt’s Macular Dystrophy and has huge
Cancer is a class of diseases that are intimately linked to stem cells. In fact, I would go so far as to call some types of cancer cells and stem cells, cousins. This concept, of a tight relationship between stem and cancer cells, is under intense investigation but at the same time it is something
Disease Focus Series: Cancer Read More »
A paper just came out in PNAS entitled “Promotion of direct reprogramming by transformation-deficient Myc“. The main thrust of this paper is that the tumorigenic and pluripotency-related functions of Myc could be separated. It focused primarily on the lesser studied LMyc. The topic of the intertwined good (pluripotency) and bad (tumorigenicity) functions of Myc, addressed
Tumorigenicity and Pluripotency teased apart? Not yet for Myc Read More »