2,000 is a big number. As of this week I’ve now published 2,000 posts here on The Niche since I started back in early 2010. I can’t quite believe it myself. To celebrate that milestone, I have revamped The Niche in terms of its organization and style with the help of a very skilled web […]
The Niche’s 2,000th post: where do we go from here? Read More »
Hans Keirstead is one of the top stem cell scientists in the world who has been doing cutting edge research including on using stem cells to reverse paralysis where he teamed up with super patient advocate Roman Reed (see the two pictured at right), but now he is also running for Congress. How cool is that?
Hans Keirstead interview on his congressional run, how you can help Read More »
The Future of Genomic Medicine conference last week down in La Jolla at Scripps was one of my favorite meetings ever. I wish I had time to have live blogged it more beyond the one post I did about some gene editing talks. Below I discuss 10 top takeaways from this great meeting that I’m planning to attend
10 takeaways from Future of Genomic Medicine meeting Read More »
Editor’s note: this is a guest post from Dr. Semenow on her new educational DNA game that also invokes stem cells. She has the remarkable distinction of having been the first woman who was a science Ph.D. student at Caltech. Stay tuned for my coming interview with her on her experiences in science. Her Kickstarter campaign
DNA Ahead Game & More Struts Its Stuff Read More »
By Gaetan Burgio CRISPR/Cas9 genome editing has dramatically changed our way to perform biological experiments. While highly efficient and easy to use, one limitation with CRISPR/Cas9 mediated genome editing technology is the occurrence of off-target effects and the restriction of the PAM recognition sequence. Many modifications from the original system have been proposed to improve
Gaetan Burgio New Data & Theory on NgAgo versus CRISPR Read More »
Today a new Nature paper from Dr. Mary Herbert’s group in the UK has found a key problem with mitochondrial replacement therapy that fits with data from others. The goal of preventing mitochondrial disease using various kinds of genome transfer technologies is a noble one, but mitochondrial replacement therapy has faced a number of technological
New Herbert lab Nature paper reinforces mitochondrial replacement Achilles heel Read More »
The second session at our CRISPR meeting was really powerful. As with other posts from the UC Davis CRISPR meeting, since I was taking notes on the fly during this session, this post is a stream of bits from the different talks, often trying to capture the essence of key questions or ideas as the speakers
UC Davis CRISPR Meeting Panel: A View from the Trenches on Human Disease Read More »
Editor’s note. Caroline Simons attended both the April 28th (see her report on that here) and 29th Paris meetings on human gene editing/genetic modification. Today, we have her in depth report on the April 29th meeting. I have posted her piece in full with only minor edits. If you are in a rush you can
In Depth Report from April 29th Paris Human Gene Edit Meeting Read More »
Editors note: This is a guest post from Caroline Simons who is attending the two Paris meetings on human gene editing. For more background on those meetings see here. By Caroline Simons There were just over a hundred participants at the workshop organized by the Federation of European Academies of Medicine, the UK Academy of
Paris human gene editing workshop summary Read More »
I talked last year about human genetic modification by CRISPR with George Church a year ago. Now we’ve followed up with a long chat on this topic going into much more detail and with questions on recent developments. Each question is listed numerically and then there is a back and forth on that question with George
George Church chat: CRISPR people, Zika, weapons Read More »