Search Results for: Dieter Egli

Mitochondrial Replacement Hype Goes Nuclear Including by Wellcome Trust

February 1, 2021 / By / 4 Comments
BBC-hype-mito-replacement

A new paper from a UK team yesterday showed that mitochondrial replacement therapy faces a serious and difficult safety hurdle fitting with similar findings from an earlier recent study from a different team led by Dieter Egli, but the UK media and some scientists there are engaging in hype, claiming the exact opposite. They are pushing the unscientific …

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New Herbert lab Nature paper reinforces mitochondrial replacement Achilles heel

February 1, 2021 / By / 1 Comment
Herbert-mitochondria-Nature-paper

Today a new Nature paper from Dr. Mary Herbert’s group in the UK has found a key problem with mitochondrial replacement therapy that fits with data from others. The goal of preventing mitochondrial disease using various kinds of genome transfer technologies is a noble one, but mitochondrial replacement therapy has faced a number of technological …

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New Mitalipov paper on stem cell mitochondria: challenge for IPS cell field?

February 1, 2021 / By / 11 Comments
Mitalipov-mitochondrial-mutations

A new paper from Shoukhrat Mitalipov’s lab on stem cell mitochondria points to a pattern whereby induced pluripotent stem (IPS) cells tend to have more problems if they are from older patients. What does this paper mean for the stem cell field and could it impact more specifically the clinical applications of IPS cells? The new …

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Future of Somatic Cell Nuclear Transfer to make ES Cells

February 1, 2021 / By / 3 Comments
NT-ESC-versus-IPSC

Advances in therapeutic cloning reported in the past year have been very exciting as somatic cell nuclear transfer (SCNT) can be used to produce very powerful human embryonic stem cells (ESC). These new cells are called NT-ESCs for short. Neither embryos nor reprogramming factors are needed to produce human NT-ESCs. See here, here and here for discussions of the pioneering papers reporting creation of …

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Cloning is cloned again: New Nature Paper is 3rd on Human SCNT

February 1, 2021 / By
Yamada-Extended-Data-SCNT

A new human therapeutic cloning paper is out today, the third in a matter of months. This one is from the lab group of Dr. Dieter Egli published in Nature demonstrating production of nuclear transfer embryonic stem cells (NT-ESCs) from an adult human somatic donor via somatic cell nuclear transfer (SCNT). This human SCNT paper follows …

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