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Countering that Pro-Heritable Human CRISPR WSJ Piece

October 22, 2017 / Professor Paul Knoepfler, Ph.D. / 9 Comments

It’s germline, heritable human CRISPR time, right? Wrong. But the particularly enthusiastic supporters of heritable human CRISPR often cite hypothetical benefits in glowing terms, but either don’t mention risks or strongly downplay them. These fans also tend to leave alternative, proven and safe technologies such as preimplantation genetic diagnosis (PGD) out of the discussion or […]

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TGIF stem cell weekend reads of papers & news

October 13, 2017 / Professor Paul Knoepfler, Ph.D.

Bulls-eye! Here are some stem cell weekend reads including both interesting new papers & news headlines. Of course, this week also had stem cell awareness day and I wrote about 10 key issues for the field for the coming 10 years! Weekend reads Papers Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during

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Why Mitalipov’s ‘magic’ room for human embryo CRISPR may give us pause

October 3, 2017 / Professor Paul Knoepfler, Ph.D. / 7 Comments

The debate over whether the main conclusions of the Nature paper on human embryo CRISPR led by Shoukhrat Mitalipov’s lab at Oregon Health Sciences University (OHSU) are correct remains unresolved. Note that Nature just added an editorial alert just above the references section to their paper: “Updated online 02 October 2017. Editorial Note: Readers are alerted that some

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Science hype award for worst CRISPR headline

September 24, 2017 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Science hype is one of the more troublesome issues in our field today especially at its interface with the media, and unfortunately a ‘great’ example of that came this past week in a headline from the Daily Mail on the new CRISPR of human embryos paper from Kathy Niakan’s group in the UK. Although Niakan’s

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1st Knockout Human Embryos Made with CRISPR: My Take on the Pub

September 20, 2017 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Fogarty-Fig-3d-human-embryo-CRISPR-e1505774206656

Scientist make knockout human embryos with CRISPR? Today we see a new Nature paper (Fogarty, et al.) on CRISPR “gene editing” of human embryos, this time from the UK from Kathy Niakan’s group. Niakan got UK permission about 18 months ago to CRISPR healthy human embryos so they’ve been hard at work since. Because Fredrik

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Mulling over that Mitalipov human embryo CRISPR pub, still many questions

September 12, 2017 / Professor Paul Knoepfler, Ph.D. / 6 Comments

What really happened at the DNA level in the experiments in that high-profile CRISPR of human embryos paper from a team led by Shoukhrat Mitalipov at OHSU? Is the team right that they successfully conducted CRISPR of human embryos to correct a mutant gene, as they reported in their Ma, et al. Nature paper? Or is the Egli,

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Mitalipov briefly responds to Egli preprint, stands by human embryo CRISPR pub findings

August 31, 2017 / Professor Paul Knoepfler, Ph.D. / 16 Comments

There has been a wave of intense discussions both in the public domain such as on Twitter and behind the scenes over the new Egli, et al. preprint that challenges the main conclusions of the Ma, et al. Nature paper from Shoukhrat Mitalipov’s lab. Ma, et al. reported CRISPR gene editing of human embryos, arguing for

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CRISPRcon guest post: Hope for a brighter future

August 19, 2017 / Professor Paul Knoepfler, Ph.D.

By Anna Everette “In our society, we have an addiction to vertical genetic transmission. It’s called sex and having a child who looks like you”. This was perhaps the most memorable quote from the event’s keynote speaker, Greg Simon, Director of the Biden Cancer Initiative. It also happens to highlight the most compelling reason to

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Review of Mitalipov paper CRISPR’ing human embryos: transformative work on the edge

August 2, 2017 / Professor Paul Knoepfler, Ph.D. / 3 Comments

In the same way perhaps that some excited relatives or parents-to-be both gush and worry about a baby before it is even born, our field has been transfixed for a week by the Mitalipov paper on CRISPR’ing human embryos even though the paper just now came out. Now that the paper is out, we can

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Big 5 questions anticipating Mitalipov human embryo CRISPR paper

July 31, 2017 / Professor Paul Knoepfler, Ph.D.

The human embryo CRISPR paper with Shoukhrat Mitalipov as senior author is coming soon. It will reportedly be focused on the use of CRISPR to genetically modify viable human embryos for reversal of a disease-associated mutation. While strangely press already broke early on this paper last week, as much as a week before the paper

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