Search Results for: Gene Editing

Recommended reads: click editing, CRISPR v. progeria, diapause transcriptional program

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click editing

Gene editing continues to advance both in the clinic trial arena and at more basic science levels including a report on a new approach called click editing. The two gene editing papers below highlight the variety of tools now available. Gene Editing papers including click editing Click editing enables programmable genome writing using DNA polymerases […]

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Recommended reads: gov scientists fear Trump 2nd term, MYCT1 in HSCs, in vivo editing

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Trump

I’ve only met one scientist who was openly a Trump fan, but I’m sure there are more out there. Still, it seems most scientists are no fans of the former president. A new WaPo piece highlights how federal scientists are worrying about a possible second term for the former president. Government scientists & a second

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Is Liz Parrish the world’s most genetically modified person? Why it might not be such a good thing

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Liz Parrish, BioViva

Some recent claims had me wondering whether Liz Parrish is the world’s most genetically modified person. She and her firm BioViva are making that claim. It’s an important question but maybe not for the reason many of us first might think. This is not really about one person. Instead, this is a weighty question because

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Weekly reads: Vertex & CRISPR Therapeutics, Arnold Caplan death, MS genetics

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CRISPR Therapeutics

The biotechs Vertex and CRISPR Therapeutics have an interesting relationship as biotechs. They are partners are multiple levels but also are very different as companies including in size. There’s been a key development in one of their partnerships. Before we jump into that, please check out the video version of my 20 stem cell and

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20 stem cell & regenerative medicine predictions for 2024

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Stem cell, crystal ball, predictions

Each year I make predictions for the stem cell and regenerative medicine field for the following year. Today’s prediction post is focused on what to expect in 2024. You can also see my stem cell predictions for 2023 and my grades on how I did. I also have made a video version of these predictions so please

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2023 stem cell predictions grades reflect wild year for regenerative medicine

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stem cell predictions

Every year I make stem cell and regenerative medicine predictions. Looking at my predictions for 2023, they reflect a wild year but in many ways a good one overall. Below I have graded my 2023 predictions. Overall, my crystal ball gave solid results. Some of the predictions have been condensed to keep things concise, but you

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Weekly reads: FDA OKs 2 gene therapies for sickle cell, new Paolo Macchiarini series, Fujifilm

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Marie Tornyenu, Casgevy gene therapies for sickle cell

The big news broke Friday that the FDA approved two new gene therapies for sickle cell disease. While the approvals were expected and the actual use of these treatments will be complex on several levels, this is a historic development. 2 FDA-approved gene therapies for sickle cell Friday’s news follows on recent UK approval for

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Weekly reads: clonal expansion, Golden Retriever cancer, FTC hits genetics firm on testi-phony-als

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clonal selection

Let’s start this week’s digest with a discussion of clonal expansion and mutations during cell and gene therapy development. Here’s the article that brought this to mind. Sickle cell gene therapy process may cause cancer-linked mutations in blood stem cells, Fierce Biotech. Clonal expansion This is a story about a non-CRISPR gene therapy using a

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Weekly reads: gene therapy nod, Nature pub ethics, CRISPR LDL

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Multipotent & totipotent vs pluripotent stem cells, very early human embryos totipotent stem cells

Totipotency literally means all powerful, but it refers in biology to specific cells. These cells can make every type of cell in the body of an organism plus the extraembryonic tissues needed for development. This includes humans. So if you could reprogram human cells like blood or skin cells into totipotent stem cells, you might

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