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National Academies panel leaves door a crack open to future human genetic modification

February 14, 2017 / Professor Paul Knoepfler, Ph.D. / 6 Comments

A National Academies panel on human genome editing chaired by Alta Charo and Richard Hynes released its report today. While it covered both somatic and germline (heritable) human genetic modification, the latter topic is far more contentious. You can see the National Academies summary of their report here. You can read the full report here. […]

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Hateful politics infiltrate human genome editing debate in France

June 27, 2016 / Professor Paul Knoepfler, Ph.D. / 1 Comment

By Elliot Hosman Summary. A campaign calling for a moratorium on using CRISPR in human embryos was launched by a prominent French organization fighting for narrow understandings of life and family. A recent campaign calling for a ban on “transgenic” human embryos was launched by one of France’s most prominent organizations fighting for “science”-backed “one-man-one-woman”

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In Depth Report from April 29th Paris Human Gene Edit Meeting

May 11, 2016 / Professor Paul Knoepfler, Ph.D.

Editor’s note. Caroline Simons attended both the April 28th (see her report on that here) and 29th Paris meetings on human gene editing/genetic modification. Today, we have her in depth report on the April 29th meeting. I have posted her piece in full with only minor edits. If you are in a rush you can

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Alliance for Regenerative Medicine (ARM) Opposes REGROW Act, Risks to Patients Cited

April 10, 2016 / Professor Paul Knoepfler, Ph.D. / 31 Comments

The biggest debate today in the stem cell world is over how much regulation is needed for new, investigational stem cell therapies that are not as yet approved. Sometimes it feels very lonely being out there publicly advocating for appropriately thorough regulation of stem cell therapies and at times I get a lot of heat for

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Nuffield Council on #Bioethics: Open call on genetic modification of humans & other organisms

January 11, 2016 / Professor Paul Knoepfler, Ph.D.

The Nuffield Council on Bioethics has released an open call for information and comments on genetic modification, including on humans and other organisms. I strongly encourage readers to participate and voice your opinions, regardless of whether you lean toward caution or taking risks on genetic modification. Your input will be important for how the Nuffield

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Just freakin do it: patients voice impatience on CRISPR for genetic diseases

December 15, 2015 / Professor Paul Knoepfler, Ph.D. / 11 Comments

Both before and particularly now after the big human gene editing summit in Washington, D.C. at the National Academy of Sciences, I’ve talked with patients about their views on this new technology including at last week’s World Stem Cell Summit. One of the most striking moments of the DC summit was when the mother of

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Perspectives: no human genetic modification moratorium from organizers of #GeneEditSummit

December 4, 2015 / Professor Paul Knoepfler, Ph.D. / 7 Comments

I just got back from a historic summit on human genetic modification in Washington, D.C. New genetic modification technology, termed CRISPR-Cas9, has both made genetic modification a relatively simple matter for scientists and human genetic modification much more likely in the near future. Heritable human genetic modification could prevent some rare genetic diseases so there

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Highlights from day 2 of #GeneEditSummit

December 3, 2015 / Professor Paul Knoepfler, Ph.D.

Day 2 of the Human Gene Editing Summit in DC (#GeneEditSummit) was quite interesting and added more depth to the meeting overall. For specific talks, see my two posts from yesterday here and here. Also see my top takeaways from Day 1. What were the top highlights of Day 2 of #GeneEditSummit? Somatic work. We

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Live Blog #GeneEditSummit Day 2 Post #2: International Governance

December 2, 2015 / Professor Paul Knoepfler, Ph.D.

How do governance issues for human genome editing work at the international level? Indira Nath, All India Institute of Medical Sciences, gives a nice overview to start the session. She raised the example of medical tourism and surrogacy in India. She argued for an international consensus on what is permissible on human gene editing. How

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Live Blogging #GeneEditSummit Day 1 Post #3: human germline modification

December 1, 2015 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Robin-Lovell-Badge-Peter-Braude-George-Church

The post-lunch session is “Applications of Gene Editing Technology: Human Germline Modification”. Prior to hearing it I’m curious how cautious or gung-ho the speakers will be, or if their gestalt will be one of balance in the middle somewhere. Robin Lovell-Badge, The Francis Crick Institute, was the moderator of this session. He said, “We’d be

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