At a genetic level, just how much do each of us human beings vary from each other in our total genome sequence? The number I was taught in Genetics at some point was that the genomes of any two human beings are likely to be 99.9% identical. So only about 1 out of 1,000 bp […]
How much human genetic variability is there really? Read More »
As CRISPR gene editing technology has advanced in the last few years, the number of genetically modified animals made with this system has steadily increased. Some are very interesting and useful for science. At the same time especially when they are little, they can be very cute. A nickname is going around for these GM
CRISPR critters: Cute pics of Cas9 gene edited animals Read More »
Heritable human genetic modification has been the topic of the year so far, but another trend is edgy and interesting: non-heritable, but cutting edge forms of human modification that in some ways fall into the class of biohacking. Biohackers are into do-it-yourself (DIY) forms of biology including self-modification. Sure, people have been modifying themselves for
DIY human ‘upgrades’ via biohacking Read More »
A decade ago I wrote an article in the journal Nature Biotechnology about the rise of a new gene editing technology called zinc finger nucleases (ZNF). It was one of those “drumbeat” discoveries: at the time, my sense was it would revolutionize how we deliver genes to cells and tissues, and profoundly change the way
Guest Post by Chris Scott–The Great CRISPR Controversy: What’s Next? Read More »
Last Thursday I participated in a meeting at Stanford Law School on human germline genetic modification hosted by Hank Greely (pictured at left), Professor of Law and Genetics at Stanford. The meeting was entitled, “Human Germline Modification: Medicine, Science, Ethics, and Law”. The panel included in addition to Hank and me, the following speakers: Marcy Darnovsky, Executive Director of
Stanford Human Germline Modification Meeting: Medicine, Science, Ethics, & Law Read More »
What is a GMO? I realized a few years ago that I really should know a lot more about the whole debate over genetically modified (GM) organisms (GMOs). What are the facts on GMOs? As a scientist who has for many years done amongst other things genetics research including making and studying so-called “knockout mice”
GMO: Why 3 Such Difficult Little Letters? Read More »
I recently interviewed leading genomics scientist George Church on the ways that trends in genomics are changing our world. We also discussed the possibility of heritable human genetic modification. These days we more often call this “CRISPR babies.” His answers suggest that genomics and gene editing are poised to radically change our world. They could literally
George Church on Germline Human Genetic Modification Read More »
A question that has come up with advances in stem cell technology: could same-sex couples have their own biological children? Since Shinya Yamanaka reprogrammed first mouse and then human ordinary cells into powerful pluripotent stem cells, termed induced pluripotent stem (iPS) cells, back in 2006-2007 many new research avenues have opened up. The impossible suddenly
Are babies from same-sex couples possible? Read More »
The science reads on my radar screen to read in my ample spare time as I work the weekend on literally 5 different grants include these pieces: NECSS and SfSBM: A weekend of science and skepticism Breaking Down Fat: Trends in adipose cell-based clinical trials PubPeer Selections: Odd citations, “practice makes perfect,” a Nature update
Recommended Weekend Science Reads Read More »
With the House of Lords vote yesterday, the UK officially became the only country in the world to have legalized human genetic modification via 3-Person IVF. The point of this “mitochondrial transfer” or “3-person IVF” technology is not directly to genetically modify humans specifically, but it still will lead to that result in any case.
UK OKs 3-Person IVF: Perspectives Read More »